TDRD TD34+CTD
Protein Sequence
Sequence Variants
| ID | Name | Remain region | Mutation sites | Ref seq |
|---|---|---|---|---|
| psp03075 | TDRD1 | 1-1172 | - | ✓ |
| psp05097 | TDRD TD34+CTD | 681-1172 | - | |
| psp00095 | TDRD1 ΔTD2 | 1-462, 678-1172 | - | |
| psp00145 | TDRD1-ΔNTD | 130-1172 | - | |
| psp00388 | TDRD1 TD2+CTD | 461-679, 1079-1172 | - | |
| psp00593 | TDRD1 1-1140 | 1-1140 | - | |
| psp01499 | TDRD1 ΔTD | 1-231, 1114-1172 | - | |
| psp01533 | TDRD1 ΔTD1 | 1-231, 442-1172 | - | |
| psp01955 | TDRD1 1-1155 | 1-1155 | - | |
| psp02053 | TDRD1-ΔIDR | 231-1172 | - | |
| psp02145 | TDRD1 TD1+CTD | 231-460, 1080-1172 | - | |
| psp02221 | TDRD1 ΔTD4 | 1-915, 1114-1172 | - | |
| psp02362 | TDRD1 ΔTD3 | 1-691, 893-1172 | - | |
| psp02808 | TDRD1 1-1160 | 1-1160 | - | |
| psp03096 | TDRD1 1-1145 | 1-1145 | - | |
| psp04394 | TDRD1 TD4+CTD | 906-1172 | - | |
| psp04405 | TDRD1 1-1150 | 1-1150 | - | |
| psp04809 | TDRD1 TD3+CTD | 681-905, 1080-1172 | - | |
| psp05013 | TDRD TD234+CTD | 461-1172 | - | |
| psp00168 | TDRD1-3GS (1149-1154 GSGSGS) | - | I1149G, L1150S, L1151G, F1152S, L1153G, L1154S | |
| psp01799 | TDRD-1 GS-1 | - | I1149G, L1150S | |
| psp02107 | TDRD-1 GS-2 | - | L1151G, F1152S | |
| psp02123 | TDRD1 I1149E | - | I1149E | |
| psp02349 | TDRD1 Y554L&Y774L | - | Y554L, Y774L | |
| psp02760 | TDRD1 Y774L | - | Y774L | |
| psp02995 | TDRD1-6A | - | I1149A, L1150A, L1151A, F1152A, L1153A, L1154A | |
| psp03449 | TDRD1 F1152E | - | F1152E | |
| psp03519 | TDRD-1 GS-3 | - | L1153G, L1154S | |
| psp04316 | TDRD1 L1154E | - | L1154E | |
| psp04620 | TDRD1 L1153E | - | L1153E | |
| psp04699 | TDRD1 L1150E | - | L1150E | |
| psp05103 | TDRD1 L1151E | - | L1151E | |
| psp05180 | TDRD1 Y554L | - | Y554L | |
| psp02867 | DmVeneno+mouse TDRD1 CTD | - | - | |
| psp03821 | DmVret+mouse TDRD1 CTD | - | - | |
| psp03905 | DmKots+mouse TDRD1 CTD | - | - |
Orthologs and Paralogs
| ID | Name | Organism | Length |
|---|---|---|---|
| psp00674 | Vret | Drosophila melanogaster | 642 |
| psp03691 | Kots | Drosophila melanogaster | 892 |
| psp03502 | TDRD1 | Homo sapiens | 1180 |
| psp04009 | TDRD1 | Xenopus tropicalis | 1162 |
| psp00260 | TDRD1 | Gallus gallus | 1035 |
| psp01007 | TDRD1 | Alligator sinensis | 1165 |
| psp04659 | TDRD1 | Danio rerio | 1175 |
| psp02999 | Veneno | Drosophila melanogaster | 691 |
Biophysical Features
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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.
Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.
NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.
Polarity was computated by ProtScale, please refer to: ProtScale.
SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.
Protein Structure
Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.
For pLDDT, please refer to: pLDDT: Understanding local confidence