nucleocapsid protein 11SD in SR

ID psp00896
Organism SARS-CoV-2
Length 419

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33479198 Positive Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp03119 nucleocapsid (N) protein 1-419 -
psp00896 nucleocapsid protein 11SD in SR - S176D, S180D, S183D, S184D, S186D, S187D, S188D, S190D, S193D, S194D, S197D
psp00051 nucleocapsid protein (ΔCTD 248-366) 1-246, 366-419 -
psp00341 nucleocapsid protein d_IDR1 95-419 -
psp00738 nucleocapsid protein 49-364 49-364 -
psp00929 nucleocapsid protein ΔSR (176-206) 1-175, 207-419 -
psp01243 nucleocapsid protein d_IDR2 1-127, 298-419 -
psp01436 nucleocapsid protein d_RBD 1-49, 175-419 -
psp01610 nucleocapsid protein (Δ176-246) 1-175, 247-419 -
psp01623 nucleocapsid protein 1-364 1-364 -
psp01674 nucleocapsid protein (1-174) 1-174 -
psp01735 nucleocapsid protein 49-419 49-419 -
psp01889 nucleocapsid protein 1-246 1-246 -
psp02020 nucleocapsid protein (Δlinker 175-247) 1-174, 248-419 -
psp02770 nucleocapsid protein d_IDR3 1-352 -
psp03256 nucleocapsid protein (40-174) 40-174 -
psp03595 nucleocapsid protein d_DD 1-245, 366-419 -
psp03665 nucleocapsid protein (ΔCIDR 367-419) 1-366 -
psp04055 nucleocapsid protein Δ210-246 1-209, 247-419 -
psp04332 nucleocapsid protein (247-363) 247-363 -
psp04711 nucleocapsid protein (176-419) 176-419 -
psp04732 nucleocapsid protein (ΔNTD 44-174) 1-43, 175-419 -
psp04790 nucleocapsid protein (175-364) 175-364 -
psp05084 nucleocapsid protein (ΔNIDR 1-43) 44-419 -
psp00414 nucleocapsid protein K375E - K375E
psp00784 nucleocapsid protein K375N - K375N
psp03038 nucleocapsid protein Y109A - Y109A
psp04853 nucleocapsid protein 14SA in SR - S176A, S180A, S183A, S184A, S186A, S187A, S188A, S190A, S193A, S194A, S197A, S201A, S202A, S206A

Orthologs and Paralogs

ID Name Organism Length
psp03134 Nucleoprotein Human coronavirus 441
psp04689 Nucleoprotein Severe acute 422
psp00357 Nucleoprotein Human coronavirus 377
psp00312 Nucleoprotein MERS-CoV 411
psp01195 Nucleoprotein Human coronavirus 389
psp01517 Nucleoprotein Human coronavirus 448

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence