Nucleoprotein

Synonyms: Nucleoprotein, Protein N, ORF 7a, NC, Nucleocapsid protein

ID psp01517
Organism Human coronavirus
Length 448
Source UniProt: P33469

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37906538 Positive -

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp03134 Nucleoprotein Human coronavirus 441
psp04689 Nucleoprotein Severe acute 422
psp00357 Nucleoprotein Human coronavirus 377
psp03119 nucleocapsid (N) protein Severe acute 419
psp00312 Nucleoprotein MERS-CoV 411
psp01195 Nucleoprotein Human coronavirus 389
psp00414 nucleocapsid protein K375E SARS-CoV-2 419
psp00784 nucleocapsid protein K375N SARS-CoV-2 419
psp00896 nucleocapsid protein 11SD in SR SARS-CoV-2 419
psp03038 nucleocapsid protein Y109A SARS-CoV-2 419
psp04853 nucleocapsid protein 14SA in SR SARS-CoV-2 419
psp00051 nucleocapsid protein (ΔCTD 248-366) SARS-CoV-2 300
psp00341 nucleocapsid protein d_IDR1 SARS-CoV-2 325
psp00738 nucleocapsid protein 49-364 SARS-CoV-2 316
psp00929 nucleocapsid protein ΔSR (176-206) SARS-CoV-2 388
psp01243 nucleocapsid protein d_IDR2 SARS-CoV-2 249
psp01436 nucleocapsid protein d_RBD SARS-CoV-2 294
psp01610 nucleocapsid protein (Δ176-246) SARS-CoV-2 348
psp01623 nucleocapsid protein 1-364 SARS-CoV-2 364
psp01674 nucleocapsid protein (1-174) SARS-CoV-2 174
psp01735 nucleocapsid protein 49-419 SARS-CoV-2 371
psp01889 nucleocapsid protein 1-246 SARS-CoV-2 246
psp02020 nucleocapsid protein (Δlinker 175-247) SARS-CoV-2 346
psp02770 nucleocapsid protein d_IDR3 SARS-CoV-2 352
psp03256 nucleocapsid protein (40-174) SARS-CoV-2 135
psp03595 nucleocapsid protein d_DD SARS-CoV-2 299
psp03665 nucleocapsid protein (ΔCIDR 367-419) SARS-CoV-2 366
psp04055 nucleocapsid protein Δ210-246 SARS-CoV-2 382
psp04332 nucleocapsid protein (247-363) SARS-CoV-2 117
psp04711 nucleocapsid protein (176-419) SARS-CoV-2 244
psp04732 nucleocapsid protein (ΔNTD 44-174) SARS-CoV-2 288
psp04790 nucleocapsid protein (175-364) SARS-CoV-2 190
psp05084 nucleocapsid protein (ΔNIDR 1-43) SARS-CoV-2 376

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence