Dcp2

ID psp00734

Organism Saccharomyces cerevisiae

Length 970

Source UniProt: P53550

PS Record in Articles

Reference (Pubmed ID)	In vitro results	In vivo results
26238190	-	Positive
29078371	-	Positive
31285266	-	Positive
32553117	-	Positive
35269643	-	Positive
36972455	Positive	-

Protein Sequence

Sequence Variants

ID	Name	Remain region	Mutation sites	Ref seq
psp00734	Dcp2	1-970	-	✓
psp02213	Dcp2 301-970	301-970	-
psp03639	Dcp2 1-300	1-300	-

Orthologs and Paralogs

ID	Name	Organism	Length
psp02269	LSm14A	Homo sapiens	463
psp04468	DCP1	Drosophila melanogaster	372
psp01629	DCP5	Chlamydomonas reinhardtii	423
psp01454	DCP5	Solanum lycopersicum	566
psp02829	PAB8	Arabidopsis thaliana	671
psp01232	AT4G34110	Arabidopsis thaliana	629
psp03575	DCP2	Homo sapiens	420
psp05123	DCP5	Physcomitrium patens	666
psp00274	DCP1	Arabidopsis thaliana	367
psp03994	DCP5	Oryza sativa	690
psp01966	AT2G23350	Arabidopsis thaliana	662
psp04617	DCP5	Arabidopsis thaliana	611
psp00565	RAP55	Xenopus laevis	471
psp01140	Scd6p	Saccharomyces cerevisiae	349
psp04576	DCP1A	Homo sapiens	582
psp01851	Dcp1	Saccharomyces cerevisiae	231
psp00282	DCP5 ICS (scrambled 1#)	Arabidopsis thaliana	210
psp01190	DCP5 ICS (scrambled 3#)	Arabidopsis thaliana	210
psp01992	DCP5 ICS (scrambled 2#)	Arabidopsis thaliana	210
psp00389	DCP5 IDR123	Arabidopsis thaliana	209
psp01114	DCP5 ΔN	Arabidopsis thaliana	523
psp01683	DCP5 ΔPrLD2	Arabidopsis thaliana	563
psp02489	DCP5 ΔIDR123	Arabidopsis thaliana	399
psp02854	DCP5 ΔC	Arabidopsis thaliana	458
psp03221	DCP5 ΔIDR1234	Arabidopsis thaliana	338
psp03888	DCP5 ICS (CR deleted)	Arabidopsis thaliana	194
psp03942	DCP5 ΔPrD	Arabidopsis thaliana	480
psp04267	DCP5 ΔIDR12	Arabidopsis thaliana	462
psp04505	DCP5 ΔIDR1	Arabidopsis thaliana	547
psp04675	DCP5 ΔIDR	Arabidopsis thaliana	248
psp04760	DCP5 ΔIDR45	Arabidopsis thaliana	459
psp00594	DCP5 ICS 23 (L to N)	Arabidopsis thaliana	209
psp00684	DCP5 ICS (F-Y)	Arabidopsis thaliana	210
psp00923	DCP5 ICS 23 (L to A)	Arabidopsis thaliana	210
psp01522	DCP5 ICS 23 (L to D)	Arabidopsis thaliana	210
psp02856	DCP5 ICS 12 (L to N)	Arabidopsis thaliana	210
psp03249	DCP5 ICS 6 (L to N)	Arabidopsis thaliana	210
psp03977	DCP5 ICS (YW-S)	Arabidopsis thaliana	210
psp04763	DCP5 ICS (CR substituted)	Arabidopsis thaliana	210
psp04871	DCP5 ICS 10 (N to L)	Arabidopsis thaliana	209
psp00891	DCP1A (CTD)	Homo sapiens	202
psp03215	DCP1A (NTD)	Homo sapiens	380
psp01072	Dcp1 Δ82-129	Saccharomyces cerevisiae	183

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence