PYCO1(W/Y→A)

ID psp00469
Organism Phaeodactylum tricornutum
Length 592

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37311001 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp03426 PYCO1 1-592 - ✓
psp00469 PYCO1(W/Y→A) - W117A, Y151A, W197A, Y221A, W273A, W315A, Y340A, W395A, Y419A, W476A, Y500A
psp00415 PYCO1(W→A) - W117A, W197A, W273A, W315A, W395A, W476A
psp01185 PYCO1(Y→A) - Y151A, Y221A, Y340A, Y419A, Y500A

Orthologs and Paralogs

ID Name Organism Length
psp02341 PYCO1 Phaeodactylum tricornutum 595
psp00619 PYCO1 45R Phaeodactylum tricornutum 175
psp00656 PYCO1 2,6R Phaeodactylum tricornutum 171
psp01017 PYCO1 56RC Phaeodactylum tricornutum 238
psp01249 PYCO1 23R Phaeodactylum tricornutum 132
psp01325 PYCO1 36RC Phaeodactylum tricornutum 361
psp01670 PYCO1 46RC Phaeodactylum tricornutum 316
psp01841 PYCO1 26RC Phaeodactylum tricornutum 434
psp02104 PYCO1 34R Phaeodactylum tricornutum 139
psp02605 PYCO1 1,6R Phaeodactylum tricornutum 175
psp02855 PYCO1 12R Phaeodactylum tricornutum 170
psp02861 PYCO1 6RC Phaeodactylum tricornutum 174
psp02877 PYCO1 56R Phaeodactylum tricornutum 178
psp01864 PYCO1 56R W476A Phaeodactylum tricornutum 178
psp02186 PYCO1 56R Y471A/W476A Phaeodactylum tricornutum 178
psp04076 PYCO1 56R R470A/R479A Phaeodactylum tricornutum 178
psp04211 PYCO1 56R K469A/K475A Phaeodactylum tricornutum 178
psp05045 PYCO1 56R Y431A/Y444A Phaeodactylum tricornutum 178

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence