hnRNPA1-LCD D262N
Protein Sequence
Sequence Variants
| ID | Name | Remain region | Mutation sites | Ref seq |
|---|---|---|---|---|
| psp03793 | hnRNPA1 | 1-320 | - | ✓ |
| psp05058 | hnRNPA1-LCD D262N | - | - | |
| psp01146 | hnRNPA1 ΔEx8 | 1-250, 303-320 | - | |
| psp01281 | hnRNPA1 LCD | 186-320 | - | |
| psp02440 | hnRNPA1 ∆hnRAC1 | 1-207, 217-320 | - | |
| psp02767 | hnRNPA1 RRM | 1-185 | - | |
| psp03145 | hnRNPA1 ∆hnRAC3 | 1-259, 267-320 | - | |
| psp03355 | hnRNPA1 ΔHexa | 1-257, 264-320 | - | |
| psp05051 | hnRNPA1 ∆hnRAC2 | 1-245, 255-320 | - | |
| psp01484 | hnRNPA1 D42R | - | D42R | |
| psp01971 | hnRNPA1 D42R/R146A | - | D42R, R146A | |
| psp03776 | hnRNPA1 V90A/R92A/S95A | - | V90A, R92A, S95A | |
| psp04049 | hnRNPA1-P288A | - | P288A | |
| psp04397 | hnRNPA1 R146A | - | R146A | |
| psp04647 | hnRNPA1 D262V | - | D262V | |
| psp04951 | hnRNPA1 (R92A-K105/106V) | - | R92A, K105V, K106V | |
| psp00143 | hnRNPA1 LCD allY 30GtoS | 141-142, 186-320 | G195S, G198S, F202Y, G203S, G205S, G207S, G209S, F210Y, G211S, F216Y, G219S, F222Y, G226S, F228Y, G229S, G233S, G235S, G238S, G241S, G243S, G246S, F247Y, G251S, F254Y, G255S, G257S, G258S, F263Y, F273Y, G278S, F281Y, G282S, G287S, P288S, Y289S, G291S, G292S, F296Y, G304S, G306S, G315S, G317S, F320Y | |
| psp01123 | hnRNPA1 LCD WT 20GtoS | 141-142, 186-320 | G195S, G203S, G205S, G207S, G209S, G211S, G219S, G226S, G233S, G238S, G243S, G246S, G255S, G257S, G278S, P288S, Y289S, G292S, G304S, G306S, G317S | |
| psp01157 | hnRNPA1 LCD allY | 141-142, 186-320 | F202Y, F210Y, F216Y, F222Y, F228Y, F247Y, F254Y, F263Y, F273Y, F281Y, P288G, Y289S, F296Y, F320Y | |
| psp01911 | hnRNPA1 LCD allY 20GtoS | 141-142, 186-320 | G195S, F202Y, G203S, G205S, G207S, G209S, F210Y, G211S, F216Y, G219S, F222Y, G226S, F228Y, G233S, G238S, G243S, G246S, F247Y, F254Y, G255S, G257S, F263Y, F273Y, G278S, F281Y, P288S, Y289S, G292S, F296Y, G304S, G306S, G317S, F320Y | |
| psp02568 | hnRNPA1 ΔEx8-Y8S | 1-250, 257-259, 306-320 | Y62S, Y124S, Y128S, Y167S, Y237S, Y244S, Y314S | |
| psp04780 | hnRNPA1 LCD WT 30GtoS | 141-142, 186-320 | G195S, G198S, G203S, G205S, G207S, G209S, G211S, G219S, G226S, G229S, G233S, G235S, G238S, G241S, G243S, G246S, G251S, G255S, G257S, G258S, G278S, G282S, G287S, P288S, Y289S, G291S, G292S, G304S, G306S, G315S, G317S | |
| psp00370 | hnRNPA1-LCD allW | - | - | |
| psp00543 | hnRNPA1-LCD V4 | - | - | |
| psp00552 | hnRNPA1-LCD -3D+3V | - | - | |
| psp00913 | hSUMO-hnRNPA1* | - | - | |
| psp01001 | hnRNPA1-LCD V1 | - | - | |
| psp01042 | AroPerfect (A1-LCD variant) | - | - | |
| psp01142 | hnRNPA1-LCD V3 | - | - | |
| psp01506 | hnRNPA1-LCD allW D262V | - | - | |
| psp01616 | hnRNPA1 IDR-CTCF | - | - | |
| psp01679 | hnRNPA1-LCD D262V | - | - | |
| psp01806 | hnRNPA1-LCD -3D+3N | - | - | |
| psp02353 | hnRNPA1-LCD | - | - | |
| psp02821 | hnRNPA1-LCD | - | - | |
| psp02885 | hnRNPA1-LCD -4D+4N | - | - | |
| psp03279 | AroPatchy (A1-LCD variant) | - | - | |
| psp03342 | hnRNPA1-LCD V5 | - | - | |
| psp03516 | hnRNPA1-LCD V2 | - | - | |
| psp04031 | hnRNPA1-LCD 11W D262V | - | - | |
| psp04138 | hnRNPA1-LCD 5W D262V | - | - | |
| psp04270 | hnRNPA1-LCD -3G1S+4V | - | - | |
| psp04483 | hnRNPA1-LCD allW D262N | - | - | |
| psp04593 | hnRNPA1-LCD -4D+4V | - | - | |
| psp04975 | hnRNPA1b | - | - |
Orthologs and Paralogs
| ID | Name | Organism | Length |
|---|---|---|---|
| psp04621 | hnRNPH3 | Homo sapiens | 346 |
| psp03290 | hnRNPL | Homo sapiens | 589 |
| psp00713 | hnRNPA2B1 | Homo sapiens | 353 |
| psp01423 | hnRNPA2 | Homo sapiens | 341 |
| psp01580 | hnRNPH2 | Homo sapiens | 449 |
| psp02668 | hnRNPA0 | Homo sapiens | 305 |
| psp02940 | hnRNPD | Homo sapiens | 355 |
| psp04197 | HNRNPF | Homo sapiens | 415 |
| psp02813 | hnRNPH1 | Homo sapiens | 449 |
| psp00430 | HNRPR | Homo sapiens | 633 |
| psp04622 | hnRNPA3 | Homo sapiens | 378 |
| psp01794 | hnRNPAB | Homo sapiens | 327 |
| psp03517 | HNRPQ | Homo sapiens | 623 |
| psp02556 | hnRNPDL | Homo sapiens | 420 |
| psp01118 | HNRNPU | Homo sapiens | 825 |
| psp02575 | HNRPK | Homo sapiens | 463 |
| psp03677 | HNRNPH1 Y210A | Homo sapiens | 449 |
| psp01241 | hnRNPH1 ΔLC1 | Homo sapiens | 360 |
| psp01559 | hnRNPH1 LC1 (192-280) | Homo sapiens | 89 |
| psp01655 | hnRNPH1 C-terminal (192-449) | Homo sapiens | 258 |
| psp01716 | hnRNPH1 (385-446) | Homo sapiens | 62 |
| psp04257 | HNRNPH1 Δ206-246 | Homo sapiens | 408 |
| psp04282 | hnRNPH1 N-terminal (1-191) | Homo sapiens | 191 |
| psp00616 | hnRNPH1 LC1 Y236/240/243S (Y3S) | Homo sapiens | 89 |
| psp02121 | hnRNPH1 LC1 Y210/219S (Y2S) | Homo sapiens | 89 |
| psp03321 | hnRNPA1L2 | Homo sapiens | 320 |
| psp02423 | hnRNPA2 P298L | Homo sapiens | 341 |
| psp04238 | hnRNPA2 D290V | Homo sapiens | 341 |
| psp03392 | hnRNPA2 LC (190-341) | Homo sapiens | 152 |
| psp03492 | hnRNPA2 LC (181-341) | Homo sapiens | 161 |
| psp05029 | hnRNPA2 LC CD, R | Homo sapiens | 146 |
| psp00723 | hnRNPA2 LC D290V | Homo sapiens | 152 |
| psp00846 | hnRNPA2 LC P298L | Homo sapiens | 152 |
| psp01039 | hnRNPA2 LC P298L | Homo sapiens | 161 |
| psp01181 | hnRNPA2 LC R→K | Homo sapiens | 152 |
| psp04022 | hnRNPD ΔEx7 | Homo sapiens | 306 |
| psp01565 | hnRNPDL (312-420) | Homo sapiens | 109 |
| psp03853 | hnRNPDL | Homo sapiens | 527 |
| psp02807 | hnRNPDL R/K+Y/F | Homo sapiens | 527 |
| psp02836 | hnRNPDL Y/F | Homo sapiens | 527 |
| psp03353 | hnRNPDL R/K | Homo sapiens | 527 |
| psp03042 | hnRNPDL isoform 2 (DL2) | Homo sapiens | 408 |
| psp04170 | hnRNPDL Nt | Homo sapiens | 227 |
| psp04395 | hnRNPDL isoform 3 (DL3) | Homo sapiens | 352 |
| psp00506 | hnRNPDL DL2N | Homo sapiens | 408 |
| psp01354 | hnRNPDL DL2H | Homo sapiens | 408 |
| psp02739 | hnRNPF 365-415 | Homo sapiens | 51 |
| psp01868 | HNRNPK 6A | Homo sapiens | 463 |
| psp00686 | HNRNPK ΔKH3 | Homo sapiens | 340 |
| psp01825 | HNRNPK-IDRDEL | Homo sapiens | 233 |
| psp02532 | HNRNPK IDR | Homo sapiens | 192 |
| psp03092 | HNRNPK-IDRMUT | Homo sapiens | 192 |
| psp01311 | hnRNPL (IDR2delP) | Homo sapiens | 581 |
| psp02144 | hnRNPL (IDR1delG) | Homo sapiens | 573 |
| psp02576 | SYNCRIP c.1518_1519insC | Homo sapiens | 553 |
| psp03688 | SYNCRIP c.854dupA | Homo sapiens | 325 |
| psp04207 | SYNCRIP c.858_859del | Homo sapiens | 339 |
Biophysical Features
The chart can zoom in and zoom out by mouse wheel.
IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.
Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.
NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.
Polarity was computated by ProtScale, please refer to: ProtScale.
SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.
Protein Structure
Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.
For pLDDT, please refer to: pLDDT: Understanding local confidence