hnRNPH1

Synonyms: HNRNPH1, Heterogeneous nuclear ribonucleoprotein H, hnRNP H [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed], HNRPH1, HNRPH

ID psp02813
Organism Homo sapiens
Length 449
Source UniProt: P31943

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
29961577 Positive -
34873036 Negative -
40103198 Positive Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02813 hnRNPH1 1-449 - ✓
psp01241 hnRNPH1 ΔLC1 1-191, 281-449 -
psp01559 hnRNPH1 LC1 (192-280) 192-280 -
psp01655 hnRNPH1 C-terminal (192-449) 192-449 -
psp01716 hnRNPH1 (385-446) 385-446 -
psp04257 HNRNPH1 Δ206-246 1-205, 247-449 -
psp04282 hnRNPH1 N-terminal (1-191) 1-191 -
psp03677 HNRNPH1 Y210A - Y210A
psp00616 hnRNPH1 LC1 Y236/240/243S (Y3S) 192-280 Y236S, Y240S, Y243S
psp02121 hnRNPH1 LC1 Y210/219S (Y2S) 192-280 Y210S, Y219S

Orthologs and Paralogs

ID Name Organism Length
psp04621 hnRNPH3 Homo sapiens 346
psp03290 hnRNPL Homo sapiens 589
psp00713 hnRNPA2B1 Homo sapiens 353
psp01423 hnRNPA2 Homo sapiens 341
psp01580 hnRNPH2 Homo sapiens 449
psp02668 hnRNPA0 Homo sapiens 305
psp02940 hnRNPD Homo sapiens 355
psp04197 HNRNPF Homo sapiens 415
psp00430 HNRPR Homo sapiens 633
psp04622 hnRNPA3 Homo sapiens 378
psp01794 hnRNPAB Homo sapiens 327
psp03517 HNRPQ Homo sapiens 623
psp02556 hnRNPDL Homo sapiens 420
psp01118 HNRNPU Homo sapiens 825
psp04975 hnRNPA1b Homo sapiens 372
psp03793 hnRNPA1 Homo sapiens 320
psp02575 HNRPK Homo sapiens 463
psp00370 hnRNPA1-LCD allW Synthetic 137
psp00543 hnRNPA1-LCD V4 Homo sapiens 137
psp00552 hnRNPA1-LCD -3D+3V Synthetic 137
psp00913 hSUMO-hnRNPA1* Homo sapiens 409
psp01001 hnRNPA1-LCD V1 Homo sapiens 137
psp01042 AroPerfect (A1-LCD variant) Homo sapiens 165
psp01142 hnRNPA1-LCD V3 Homo sapiens 137
psp01506 hnRNPA1-LCD allW D262V Synthetic 137
psp01616 hnRNPA1 IDR-CTCF Synthetic 871
psp01679 hnRNPA1-LCD D262V Synthetic 137
psp01806 hnRNPA1-LCD -3D+3N Synthetic 137
psp02353 hnRNPA1-LCD Homo sapiens 137
psp02821 hnRNPA1-LCD Synthetic 137
psp02885 hnRNPA1-LCD -4D+4N Synthetic 137
psp03279 AroPatchy (A1-LCD variant) Homo sapiens 165
psp03342 hnRNPA1-LCD V5 Homo sapiens 137
psp03516 hnRNPA1-LCD V2 Homo sapiens 137
psp04031 hnRNPA1-LCD 11W D262V Homo sapiens 137
psp04138 hnRNPA1-LCD 5W D262V Homo sapiens 137
psp04270 hnRNPA1-LCD -3G1S+4V Synthetic 137
psp04483 hnRNPA1-LCD allW D262N Synthetic 137
psp04593 hnRNPA1-LCD -4D+4V Synthetic 137
psp05058 hnRNPA1-LCD D262N Synthetic 137
psp01484 hnRNPA1 D42R Homo sapiens 320
psp01971 hnRNPA1 D42R/R146A Homo sapiens 320
psp03776 hnRNPA1 V90A/R92A/S95A Homo sapiens 320
psp04049 hnRNPA1-P288A Homo sapiens 320
psp04397 hnRNPA1 R146A Homo sapiens 320
psp04647 hnRNPA1 D262V Homo sapiens 320
psp04951 hnRNPA1 (R92A-K105/106V) Homo sapiens 320
psp01146 hnRNPA1 ΔEx8 Homo sapiens 268
psp01281 hnRNPA1 LCD Homo sapiens 135
psp02440 hnRNPA1 ∆hnRAC1 Homo sapiens 311
psp02767 hnRNPA1 RRM Homo sapiens 185
psp03145 hnRNPA1 ∆hnRAC3 Homo sapiens 313
psp03355 hnRNPA1 ΔHexa Homo sapiens 314
psp05051 hnRNPA1 ∆hnRAC2 Homo sapiens 311
psp00143 hnRNPA1 LCD allY 30GtoS Homo sapiens 137
psp01123 hnRNPA1 LCD WT 20GtoS Homo sapiens 137
psp01157 hnRNPA1 LCD allY Homo sapiens 137
psp01911 hnRNPA1 LCD allY 20GtoS Homo sapiens 137
psp02568 hnRNPA1 ΔEx8-Y8S Homo sapiens 268
psp04780 hnRNPA1 LCD WT 30GtoS Homo sapiens 137
psp03321 hnRNPA1L2 Homo sapiens 320
psp02423 hnRNPA2 P298L Homo sapiens 341
psp04238 hnRNPA2 D290V Homo sapiens 341
psp03392 hnRNPA2 LC (190-341) Homo sapiens 152
psp03492 hnRNPA2 LC (181-341) Homo sapiens 161
psp05029 hnRNPA2 LC CD, R Homo sapiens 146
psp00723 hnRNPA2 LC D290V Homo sapiens 152
psp00846 hnRNPA2 LC P298L Homo sapiens 152
psp01039 hnRNPA2 LC P298L Homo sapiens 161
psp01181 hnRNPA2 LC R→K Homo sapiens 152
psp04022 hnRNPD ΔEx7 Homo sapiens 306
psp01565 hnRNPDL (312-420) Homo sapiens 109
psp03853 hnRNPDL Homo sapiens 527
psp02807 hnRNPDL R/K+Y/F Homo sapiens 527
psp02836 hnRNPDL Y/F Homo sapiens 527
psp03353 hnRNPDL R/K Homo sapiens 527
psp03042 hnRNPDL isoform 2 (DL2) Homo sapiens 408
psp04170 hnRNPDL Nt Homo sapiens 227
psp04395 hnRNPDL isoform 3 (DL3) Homo sapiens 352
psp00506 hnRNPDL DL2N Homo sapiens 408
psp01354 hnRNPDL DL2H Homo sapiens 408
psp02739 hnRNPF 365-415 Homo sapiens 51
psp01868 HNRNPK 6A Homo sapiens 463
psp00686 HNRNPK ΔKH3 Homo sapiens 340
psp01825 HNRNPK-IDRDEL Homo sapiens 233
psp02532 HNRNPK IDR Homo sapiens 192
psp03092 HNRNPK-IDRMUT Homo sapiens 192
psp01311 hnRNPL (IDR2delP) Homo sapiens 581
psp02144 hnRNPL (IDR1delG) Homo sapiens 573
psp02576 SYNCRIP c.1518_1519insC Homo sapiens 553
psp03688 SYNCRIP c.854dupA Homo sapiens 325
psp04207 SYNCRIP c.858_859del Homo sapiens 339

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence