RNF219 C52S

ID psp05023
Organism Homo sapiens
Length 726

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
40497348 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01309 RNF219 1-726 - ✓
psp05023 RNF219 C52S - C52S
psp00489 RNF219 RING-CC1 18-130 -
psp00614 RNF219 ΔCC2 1-156, 268-726 -
psp00788 RNF219 ΔRING-CC1 130-726 -
psp01631 RNF219 RING 18-56 -
psp01858 RNF219 ΔRING 78-726 -
psp03788 RNF219 ΔRING-CC1-CC2 267-726 -
psp04457 RNF219 CC1 57-130 -
psp00837 RNF219 R88W - R88W
psp01652 RNF219 V29F - V29F
psp01697 RNF219 P130S - P130S
psp02046 RNF219 E109Q - E109Q
psp02289 RNF219 C31Y - C31Y
psp02410 RNF219 C18S - C18S
psp03288 RNF219 C21S - C21S
psp03313 RNF219 H35R - H35R
psp03328 RNF219 C38S - C38S
psp03432 RNF219 C41S - C41S
psp03483 RNF219 C55W - C55W
psp01267 RNF219 RING C31Y-CC1 18-130 C31Y
psp03193 RNF219 C31Y ΔCBD 1-156, 268-606, 711-726 C31Y
psp04285 RNF219 RING C31Y 18-56 C31Y
psp04287 RNF219 C31Y ΔCC2 1-156, 268-726 C31Y

Orthologs and Paralogs

ID Name Organism Length
psp02539 GST-RNF168 IDR1-mEGFP Synthetic 663
psp02927 GST-RNF168 IDR2-mEGFP Synthetic 684
psp01183 RNF4 Homo sapiens 190
psp00521 RNF168 Homo sapiens 571
psp03810 RNF214 Homo sapiens 703
psp02230 RNF2 Homo sapiens 336
psp00453 RNF168-SUMO3 Homo sapiens 674
psp00383 RNF168 Δ460-504 Homo sapiens 526
psp01147 RNF168 Δ460-550 Homo sapiens 480
psp01946 RNF168 ΔIDR1 Homo sapiens 364
psp01981 RNF168 Δ479-550 Homo sapiens 499
psp02201 RNF168 Δ505-550 Homo sapiens 525
psp02502 RNF168 ΔLRM2 Homo sapiens 558
psp03052 RNF168 Δ323-442 Homo sapiens 451
psp03670 RNF168 ΔRING Homo sapiens 527
psp04529 RNF168 ΔIDR2 Homo sapiens 344
psp00993 RNF214 (220-379) Homo sapiens 160
psp02178 RNF214 ΔCC Homo sapiens 543
psp03862 RNF214 (1-410) Homo sapiens 410
psp05202 RNF214 (410-703) Homo sapiens 293

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence