RNF168

Synonyms: RING finger protein 168, RNF168, RING-type E3 ubiquitin transferase RNF168, hRNF168, EC 2.3.2.27, E3 ubiquitin-protein ligase RNF168

ID psp00521
Organism Homo sapiens
Length 571
Source UniProt: Q8IYW5

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38968116 Positive Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00521 RNF168 1-571 - ✓
psp00383 RNF168 Δ460-504 1-459, 505-571 -
psp01147 RNF168 Δ460-550 1-459, 551-571 -
psp01946 RNF168 ΔIDR1 1-87, 295-571 -
psp01981 RNF168 Δ479-550 1-477, 550-571 -
psp02201 RNF168 Δ505-550 1-504, 551-571 -
psp02502 RNF168 ΔLRM2 1-465, 479-571 -
psp03052 RNF168 Δ323-442 1-322, 443-571 -
psp03670 RNF168 ΔRING 1-14, 59-571 -
psp04529 RNF168 ΔIDR2 1-323, 551-571 -
psp00453 RNF168-SUMO3 - -

Orthologs and Paralogs

ID Name Organism Length
psp02539 GST-RNF168 IDR1-mEGFP Synthetic 663
psp02927 GST-RNF168 IDR2-mEGFP Synthetic 684
psp01183 RNF4 Homo sapiens 190
psp03810 RNF214 Homo sapiens 703
psp01309 RNF219 Homo sapiens 726
psp02230 RNF2 Homo sapiens 336
psp00993 RNF214 (220-379) Homo sapiens 160
psp02178 RNF214 ΔCC Homo sapiens 543
psp03862 RNF214 (1-410) Homo sapiens 410
psp05202 RNF214 (410-703) Homo sapiens 293
psp00837 RNF219 R88W Homo sapiens 726
psp01652 RNF219 V29F Homo sapiens 726
psp01697 RNF219 P130S Homo sapiens 726
psp02046 RNF219 E109Q Homo sapiens 726
psp02289 RNF219 C31Y Homo sapiens 726
psp02410 RNF219 C18S Homo sapiens 726
psp03288 RNF219 C21S Homo sapiens 726
psp03313 RNF219 H35R Homo sapiens 726
psp03328 RNF219 C38S Homo sapiens 726
psp03432 RNF219 C41S Homo sapiens 726
psp03483 RNF219 C55W Homo sapiens 726
psp05023 RNF219 C52S Homo sapiens 726
psp00489 RNF219 RING-CC1 Homo sapiens 113
psp00614 RNF219 ΔCC2 Homo sapiens 615
psp00788 RNF219 ΔRING-CC1 Homo sapiens 597
psp01631 RNF219 RING Homo sapiens 39
psp01858 RNF219 ΔRING Homo sapiens 649
psp03788 RNF219 ΔRING-CC1-CC2 Homo sapiens 460
psp04457 RNF219 CC1 Homo sapiens 74
psp01267 RNF219 RING C31Y-CC1 Homo sapiens 113
psp03193 RNF219 C31Y ΔCBD Homo sapiens 511
psp04285 RNF219 RING C31Y Homo sapiens 39
psp04287 RNF219 C31Y ΔCC2 Homo sapiens 615

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence