ATXN2 LCD M1204S

ID psp04955
Organism Homo sapiens
Length 188

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37369203 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp05217 ATXN2 1-1313 - ✓
psp04955 ATXN2 LCD M1204S 1126-1313 M1205S
psp00807 ATXN2 LCD (1125-1312) 1126-1313 -
psp03931 ATXN2 (2-1313) 2-1313 -
psp00422 ATXN2 LCD M1268S 1126-1313 M1269S
psp00544 ATXN2 LCD M1242S 1126-1313 M1243S
psp02176 ATXN2 LCD M1254S 1126-1313 M1255S
psp02773 ATXN2 LCD M1266S 1126-1313 M1267S
psp04652 ATXN2 LCD (1125-1312) all M-to-S 1126-1313 M1205S, M1243S, M1255S, M1266S, M1267S, M1269S, M1300S
psp05162 ATXN2 LCD M1265S 1126-1313 M1266S
psp05194 ATXN2 LCD M1299S 1126-1313 M1300S

Orthologs and Paralogs

ID Name Organism Length
psp04097 ATXN2L Homo sapiens 1075
psp02931 ATXN2L LCD (875-1075) Homo sapiens 201

Biophysical Features

The chart can zoom in and zoom out by mouse wheel.

IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence