ATXN2L LCD (875-1075)

ID psp02931
Organism Homo sapiens
Length 201

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37369203 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp04097 ATXN2L 1-1075 - ✓
psp02931 ATXN2L LCD (875-1075) 875-1075 -

Orthologs and Paralogs

ID Name Organism Length
psp05217 ATXN2 Homo sapiens 1313
psp03931 ATXN2 Homo sapiens 1312
psp00807 ATXN2 LCD (1125-1312) Homo sapiens 188
psp00422 ATXN2 LCD M1268S Homo sapiens 188
psp00544 ATXN2 LCD M1242S Homo sapiens 188
psp02176 ATXN2 LCD M1254S Homo sapiens 188
psp02773 ATXN2 LCD M1266S Homo sapiens 188
psp04652 ATXN2 LCD (1125-1312) all M-to-S Homo sapiens 188
psp04955 ATXN2 LCD M1204S Homo sapiens 188
psp05162 ATXN2 LCD M1265S Homo sapiens 188
psp05194 ATXN2 LCD M1299S Homo sapiens 188

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence