TRF1 ΔHinge

ID psp04477
Organism Homo sapiens
Length 331

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
35077681 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02832 TRF1 1-439 - ✓
psp04477 TRF1 ΔHinge 1-264, 373-439 -
psp00959 TRF1 HingeMyb 265-439 -
psp02589 TRF1 Hinge 265-372 -
psp02706 TRF1 ΔIDR 65-264, 373-439 -
psp02916 TRF1 ΔA 65-439 -
psp02984 TRF1 GSTHingeMyb - -
psp03072 TRF1 Basic - -

Orthologs and Paralogs

ID Name Organism Length
psp02731 TRF2 Homo sapiens 542
psp01542 TRF2 GSTSub Homo sapiens 559
psp02620 TRF2 GST-HingeMyb Homo sapiens 472
psp03127 TRF2 Acdic Homo sapiens 519
psp02209 TRF2 ΔHinge Homo sapiens 342
psp02652 TRF2 HingeMyb Homo sapiens 254
psp02763 TRF2 Hinge Homo sapiens 200
psp03708 TRF2 ΔIDR Homo sapiens 255
psp04232 TRF2 ΔTRFH Homo sapiens 341
psp04911 TRF2 ΔB Homo sapiens 455

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence