TRF2 GSTSub

ID psp01542
Organism Homo sapiens
Length 559

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
35077681 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02731 TRF2 1-542 - ✓
psp01542 TRF2 GSTSub - -
psp02209 TRF2 ΔHinge 1-288, 489-542 -
psp02652 TRF2 HingeMyb 289-542 -
psp02763 TRF2 Hinge 289-488 -
psp03708 TRF2 ΔIDR 88-288, 489-542 -
psp04232 TRF2 ΔTRFH 1-87, 289-542 -
psp04911 TRF2 ΔB 88-542 -
psp02620 TRF2 GST-HingeMyb - -
psp03127 TRF2 Acdic - -

Orthologs and Paralogs

ID Name Organism Length
psp02832 TRF1 Homo sapiens 439
psp02984 TRF1 GSTHingeMyb Homo sapiens 393
psp03072 TRF1 Basic Homo sapiens 462
psp00959 TRF1 HingeMyb Homo sapiens 175
psp02589 TRF1 Hinge Homo sapiens 108
psp02706 TRF1 ΔIDR Homo sapiens 267
psp02916 TRF1 ΔA Homo sapiens 375
psp04477 TRF1 ΔHinge Homo sapiens 331

Biophysical Features

The chart can zoom in and zoom out by mouse wheel.

IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence