PrPC Y>A

ID psp04373
Organism Homo sapiens
Length 253

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
40238918 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02179 PrP 1-253 - ✓
psp04373 PrPC Y>A - Y38A, Y49A, Y128A, Y145A, Y149A, Y150A, Y157A, Y162A, Y163A, Y169A, Y218A, Y225A, Y226A
psp00209 PrP 125-231 125-231 -
psp00472 Prion 1-144 1-144 -
psp03467 PrP 200-231 200-231 -
psp03690 PrP 23-231 23-231 -
psp04541 PrP 125-199 125-199 -
psp00290 PrPC K>A - K23A, K24A, K27A, K101A, K104A, K106A, K110A, K185A, K194A, K204A
psp00454 PrP G127K - G127K
psp00707 PrP G127V - G127V
psp01784 PrP G127E - G127E
psp02014 PrPC DE>A - D18A, D144A, E146A, D147A, E152A, D167A, E168A, D178A, E196A, E200A, D202A, E207A, E211A, E219A, E221A
psp03381 PrP G127I - G127I
psp03852 PrP G127A - G127A
psp04794 PrPC T>A - T15A, T33A, T95A, T107A, T183A, T188A, T190A, T191A, T192A, T193A, T199A, T201A, T216A
psp04799 PrP G127W - G127W
psp04818 PrPC S>A - S17A, S36A, S43A, S97A, S103A, S132A, S135A, S143A, S170A, S222A, S230A, S231A, S236A, S237A, S245A
psp00541 Prion 1-144 A→V 1-144 A113V, A115V, A117V
psp01528 Prion 1-144 A→G 1-144 A113G, A115G, A117G
psp02594 PrP 125-231 T199A 125-231 T199A
psp04003 PrP 125-231 T201A 125-231 T201A

Orthologs and Paralogs

ID Name Organism Length
psp02004 PrP Mus musculus 254
psp03282 PrP N2 (23-89) Mus musculus 67
psp03636 PrP N1 (23-114) Mus musculus 92
psp03725 PrP 23-231 Mus musculus 209
psp04797 PrP 90-231 Mus musculus 142
psp00265 PrP N1_PB2>R Mus musculus 92
psp00466 MoPrP Mus musculus 210
psp00718 PrP N1_PB1>A Mus musculus 92
psp00860 MoPrP-ORΔH Mus musculus 210
psp00882 MoN1-ORΔW Mus musculus 93
psp01032 PrP N1_PB2>A Mus musculus 92
psp01597 MoN1 Mus musculus 92
psp02155 PrP N1_W|Y>G Mus musculus 92
psp02528 MoPrP-ORΔW Mus musculus 210
psp04418 PrP N1_PB1+2>A Mus musculus 92
psp04821 MoN1-ORΔH Mus musculus 93

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence