PrP N1 (23-114)

ID psp03636
Organism Mus musculus
Length 92

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
34102212 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02004 PrP 1-254 - ✓
psp03636 PrP N1 (23-114) 23-114 -
psp03282 PrP N2 (23-89) 23-88, 254-254 -
psp03725 PrP 23-231 23-231 -
psp04797 PrP 90-231 90-231 -
psp00265 PrP N1_PB2>R 23-114 K100R, P101R, S102R, K103R, P104R, K105R
psp00466 MoPrP 1-1, 23-231 L108M, V111M
psp00718 PrP N1_PB1>A 1-2, 10-10, 26-114 M1A, P26A, K27A
psp00860 MoPrP-ORΔH 1-1, 23-231 H60G, H68G, H76G, H84G, L108M, V111M, V208W
psp00882 MoN1-ORΔW 1-1, 23-114 W56G, W64G, W72G, W80G, W88G, L108M, V111M
psp01032 PrP N1_PB2>A 23-114 K100A, P101A, S102A, K103A, P104A, K105A
psp01597 MoN1 1-1, 23-57, 59-114 L108M, V111M
psp02155 PrP N1_W|Y>G 23-114 W31G, Y38G, Y49G, W56G, W64G, W72G, W80G, W88G, W98G
psp02528 MoPrP-ORΔW 1-1, 23-231 W56G, W64G, W72G, W80G, W88G, L108M, V111M
psp04418 PrP N1_PB1+2>A 1-2, 10-10, 26-114 M1A, P26A, K27A, K100A, P101A, S102A, K103A, P104A, K105A
psp04821 MoN1-ORΔH 1-1, 23-114 H60G, H68G, H76G, H84G, L108M, V111M

Orthologs and Paralogs

ID Name Organism Length
psp02179 PrP Homo sapiens 253
psp00290 PrPC K>A Homo sapiens 253
psp00454 PrP G127K Homo sapiens 253
psp00707 PrP G127V Homo sapiens 253
psp01784 PrP G127E Homo sapiens 253
psp02014 PrPC DE>A Homo sapiens 253
psp03381 PrP G127I Homo sapiens 253
psp03852 PrP G127A Homo sapiens 253
psp04373 PrPC Y>A Homo sapiens 253
psp04794 PrPC T>A Homo sapiens 253
psp04799 PrP G127W Homo sapiens 253
psp04818 PrPC S>A Homo sapiens 253
psp00209 PrP 125-231 Homo sapiens 107
psp00472 Prion 1-144 Homo sapiens 144
psp03467 PrP 200-231 Homo sapiens 32
psp03690 PrP 23-231 Homo sapiens 209
psp04541 PrP 125-199 Homo sapiens 75
psp00541 Prion 1-144 A→V Homo sapiens 144
psp01528 Prion 1-144 A→G Homo sapiens 144
psp02594 PrP 125-231 T199A Homo sapiens 107
psp04003 PrP 125-231 T201A Homo sapiens 107

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence