TDP43 CTD M-S

ID psp04343
Organism Homo sapiens
Length 152

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
31653829 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01574 TDP-43 1-414 - ✓
psp04343 TDP43 CTD M-S 263-414 M307S, M311S, M359S, M405S, M414S
psp00072 TDP43-LCD (267-414) 267-414 -
psp00336 TDP-43 ΔN(102-414) 102-414 -
psp00476 TDP-43 1-274 ΔRRM2 1-190, 262-274 -
psp00644 TDP-43Δ40-53 1-39, 54-414 -
psp00813 TDP-43 1-274 1-274 -
psp00845 TDP-43 332-342 332-342 -
psp00853 TDP-43Δ76-100 1-74, 100-414 -
psp00940 TDP-43 RRM1-2(102-269) 102-269 -
psp01106 TDP-43 (Δ274-319) 1-274, 320-414 -
psp01416 TDP-43 (Δ316-346) 1-315, 347-414 -
psp01672 TDP-43 (Δ320-366) 1-319, 367-414 -
psp01741 TDP-43 332-348 332-348 -
psp01830 TDP-43 312-327 312-327 -
psp02094 TDP-43 NTD 2-80 -
psp02316 TDP-43 (1-260) 1-260 -
psp02358 Trx-TDP-43 (311-360) 311-360 -
psp02560 TDP-43 (Δ367-414) 1-366 -
psp02907 TDP-43 LCD (262-414) 262-414 -
psp03010 TDP-43 CTD (263-414) 263-414 -
psp03140 TDP-43ΔCR (321-340) 1-320, 341-414 -
psp03301 TDP-43 ΔNLS 1-81, 99-414 -
psp03309 TDP-43 193-414 193-414 -
psp03330 TDP-43 329-348 329-348 -
psp03337 TDP43 1-273 1-273 -
psp03457 TDP-43 312-318 312-318 -
psp03597 TDP-43 1-274 ΔRRM1 1-105, 182-274 -
psp03779 TDP43 100-273 100-273 -
psp03861 TDP-43 (Δ320-414) 1-319 -
psp04050 TDP-43 NTD (1-102) 1-102 -
psp04161 TDP-43C(258-414) 258-414 -
psp04410 TDP-43 ΔC(1-269) 1-269 -
psp04484 TDP-43 312-348 312-348 -
psp04729 TDP-43(1-101) 1-101 -
psp04742 TDP-43 274-414 274-414 -
psp04865 TDP-43 LCD 266-414 -
psp04909 TDP-43 316-323 316-323 -
psp00025 TDP-43 M337V - M337V
psp00089 TDP-43 K181E - K181E
psp00128 TDP-43 (W385G) - W385G
psp00183 TDP-43 (M337P) - M337P
psp00367 TDP-43 (G294A) - G294A
psp00461 TDP-43 (W412G) - W412G
psp00490 TDP-43 (W334G) - W334G
psp00582 TDP-43 (A326P) - A326P
psp00726 TDP-43 HPmut5 - I318A, M322A, L330A, M336A, M339A
psp00818 TDP-43 S48E - S48E
psp00848 TDP-43 5D - S379D, S403D, S404D, S409D, S410D
psp00966 TDP-43(F147L, F149L) - F147L, F149L
psp01108 TDP-43 12D - S373D, S375D, S379D, S387D, S389D, S393D, S395D, S403D, S404D, S407D, S409D, S410D
psp01141 TDP-43 (G335A) - G335A
psp01340 TDP-43 A315E - A315E
psp01786 TDP-43(F147L,F149L,F229L,F231L) - F147L, F149L, F229L, F231L
psp02029 TDP-43 (W334G/W412G) - W334G, W385G
psp02214 TDP-43 RRMm - F147A, F149A, F194A, F229A, F231A
psp02256 TDP-43 (K84R) - K84R
psp02265 TDP-43 (Q331K) - Q331K
psp02295 TDP-43 12A - S373A, S375A, S379A, S387A, S389A, S393A, S395A, S403A, S404A, S407A, S409A, S410A
psp02305 TDP-43 6M&RRMm - E14A, E17A, E21A, Q34A, R52A, R55A, F147A, F149A, F194A, F229A, F231A
psp02306 TDP-43 2KQ - K145Q, K192Q
psp02345 TDP-43 5FL - F147L, F149L, F194L, F231L, F234L
psp02666 TDP-43 S292E - S292E
psp02875 TDP-43 P112H - P112H
psp03056 TDP-43(Y4R,E17R) - Y4R, E17R
psp03287 TDP-43 R293F - R293F
psp03292 TDP-43-NESmut - I239A, L243A
psp03414 TDP-43 G376D - G376D
psp04118 TDP-43 S292:S409:S410E - S292E, S409E, S410E
psp04191 TDP-43 5A - S379A, S403A, S404A, S409A, S410A
psp04192 TDP-43 G294V - G294V
psp04217 TDP-43 K263E - K263E
psp04221 TDP-43 (K136Q) - K136Q
psp04312 TDP-43 2A - S409A, S410A
psp04440 TDP-43 2D - S409D, S410D
psp04446 TDP-43 G376V - G376V
psp04491 TDP-43 S409:S410E - S409E, S410E
psp04785 TDP-43 6M - E14A, E17A, E21A, Q34A, R52A, R55A
psp05066 TDP-43 (W385G/W412G) - W385G, W412G
psp00006 TDP-43 LC A328G 262-414 A328G
psp00029 TDP-43 CTD L340A 267-414 L340A
psp00076 TDP-43 LC P280G 262-414 P280G
psp00125 TDP-43 CTD S317A 267-414 S317A
psp00162 TDP-43 LCD F6-P3 262-414 A321P, M323P
psp00173 TDP-43 LC L340G 262-414 L340G
psp00179 TDP-43 LCD F6-P4 262-414 A325P, Q327P
psp00187 TDP-43 LCD F6-P1 262-414 F313P, A315P
psp00332 TDP-43 LC M322G 262-414 M322G
psp00366 TDP-43 LCD F6-P2 262-414 S317P, N319P
psp00378 TDP-43 LC A326G 262-414 A326G
psp00434 TDP-43 CTD G335N 267-414 G335N
psp00439 TDP-43 LC P320A 262-414 P320A
psp00503 TDP-43 LC M337G 262-414 M337G
psp00634 TDP-43 LC Q331G 262-414 Q331G
psp00753 TDP43 CTD VLIM-F 263-414 L270F, L299F, M307F, M311F, I318F, M359F, I383F, M405F, M414F
psp00782 TDP-43 LC P320G 262-414 P320G
psp00867 TDP-43 LC S332G 262-414 S332G
psp00998 TDP-43 LC G335S 262-414 G335S
psp01029 TDP-43 LCD F6-P6 262-414 S333P, G335P
psp01038 TDP-43 267-414 A321G 267-414 A321G
psp01087 TDP-43 CTD G335S 267-414 G335S
psp01143 TDP43 CTD K-R 263-414 K263R, K408R
psp01271 TDP43 CTD FYW-S 263-414 F276S, F283S, F289S, F313S, F316S, F367S, Y374S, W385S, F397S, F401S, W412S
psp01306 TDP-43 LCD F6-P7 262-414 M337P, M339P
psp01404 S333D TDP-43 LCD 267-414 S333D
psp01424 TDP43 CTD KRED-S 263-414 K263S, R268S, E271S, R272S, R275S, R293S, R361S, E362S, D406S, K408S
psp01473 TDP-43 CTD M336A 267-414 M336A
psp01479 TDP-43 LC A325G 262-414 A325G
psp01507 TDP-43 LC A315G 262-414 A315G
psp01526 TDP-43 267-414 A321V 267-414 A321V
psp01627 TDP43 CTD M-V 263-414 M307V, M311V, M359V, M405V, M414V
psp01747 TDP-43 LCD F6-P5 262-414 A329P, Q331P
psp01763 TDP-43 LC W334G 262-414 W334G
psp01839 TDP-43 CTD Q331A 267-414 Q331A
psp01850 TDP-43 CTD S332A 267-414 S332A
psp01894 TDP-43 CTD Q327A 267-414 Q327A
psp01924 TDP-43 LC P320S 262-414 P320S
psp01935 TDP-43 LC M339G 262-414 M339G
psp02019 TDP-43 193-414 A315T 193-414 A315T
psp02041 TDP-43 267-414 (W334F/W385F/W412F) 267-414 W334F, W385F, W412F
psp02066 TDP-43 LC M337V 262-414 M337V
psp02081 TDP-43 CTD G335A 267-414 G335A
psp02229 TDP-43 LC P363G 262-414 P363G
psp02260 TDP-43 LC N319G 262-414 N319G
psp02350 TDP-43 LC A329G 262-414 A329G
psp02408 TDP-43 CTD I318A 267-414 I318A
psp02425 TDP-43 CTD M323A 267-414 M323A
psp02487 TDP-43 LC F316G 262-414 F316G
psp02618 TDP43 CTD F-Y 263-414 F276Y, F283Y, F289Y, F313Y, F316Y, F367Y, F397Y, F401Y
psp02665 TDP-43 LC Q327G 262-414 Q327G
psp02754 TDP-43 LC A324G 262-414 A324G
psp02893 TDP-43 267-414 M337V 267-414 M337V
psp02909 TDP-43 LC G338S 262-414 G338S
psp02959 TDP-43 LC S317G 262-414 S317G
psp03081 TDP-43 CTD Q343A 267-414 Q343A
psp03138 TDP-43 CTD L330A 267-414 L330A
psp03338 TDP-43 CTD S333A 267-414 S333A
psp03343 TDP43 CTD F-S 263-414 F276S, F283S, F289S, F313S, F316S, F367S, F397S, F401S
psp03385 TDP-43 CTD N319A 267-414 N319A
psp03406 TDP-43 CTD M337A 267-414 M337A
psp03446 TDP-43 CTD M339A 267-414 M339A
psp03470 TDP-43 CTD M322A 267-414 M322A
psp03524 TDP-43 CTD F316A 267-414 F316A
psp03527 TDP43 CTD R-K 263-414 R268K, R272K, R275K, R293K, R361K
psp03611 TDP-43 CTD W334A 267-414 W334A
psp03685 TDP-43 CTD S342A 267-414 S342A
psp04006 TDP-43 LC I318G 262-414 I318G
psp04072 TDP-43 LCD (2-PM) 266-414 S403D, S404D
psp04092 TDP-43 LCD F6-P8 262-414 L340P, S342P
psp04146 TDP-43 LC L330G 262-414 L330G
psp04159 TDP-43 LC P349G 262-414 P349G
psp04198 TDP-43 CTD G335D 267-414 G335D
psp04201 TDP-43 CTD F313A 267-414 F313A
psp04342 S332D TDP-43 LCD 267-414 S332D
psp04344 TDP-43 LC M323G 262-414 M323G
psp04642 TDP-43-K145/192R 1-274 K145R, K192R
psp04657 TDP-43 LC S333G 262-414 S333G
psp04722 TDP-43 CTD G338A 267-414 G338A
psp04739 TDP-43 1-274 D169G 1-190, 262-274 D169G
psp04770 TDP-43 LC A321G 262-414 A321G
psp04776 TDP-43 LC M336G 262-414 M336G
psp05171 TDP-43 LCD (4-PM) 266-414 S403D, S404D, S409D, S410D
psp01289 TDP-43 2D-MBP-His6 - -
psp01717 TDP-43 5A-MBP-His6 - -
psp01848 TDP-43 12A-MBP-His6 - -
psp02500 TDP-43-MBP-His6 - -
psp03453 TDP-43 2A-MBP-His6 - -
psp04034 TDP-43 12D-MBP-His6 - -
psp04928 TDP-43-MBP-His6 - -
psp05145 TDP-43 5D-MBP-His6 - -

Orthologs and Paralogs

ID Name Organism Length
psp01761 Axin1 AD7-TDP43 Homo sapiens 842
psp02746 EB1-TDP43 Synthetic 406
psp03671 TDP-43 Mus musculus 414

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence