EB1-TDP43

ID psp02746
Organism Synthetic
Length 406

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
36536176 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02619 EB1 1-268 - ✓
psp02746 EB1-TDP43 - -
psp02279 EB1 K220Q - K220Q
psp02479 EB1 K174Q - K174Q
psp04439 EB1 K174R - K174R
psp04862 EB1-KR6Q - K148Q, K150Q, K151Q, K174Q, R181Q, K182Q
psp00191 EB1-Pub1-WT - -
psp01728 EB1-Pub1-KR5Q - -
psp02156 EB1-hnRNPA1 - -
psp03428 EB1-RDI - -
psp04492 EB1-hnRNPA1_D262V - -
psp04704 EB1-FUS - -

Orthologs and Paralogs

ID Name Organism Length
psp01761 Axin1 AD7-TDP43 Homo sapiens 842
psp03671 TDP-43 Mus musculus 414
psp01574 TDP-43 Homo sapiens 414
psp01289 TDP-43 2D-MBP-His6 Homo sapiens 808
psp01717 TDP-43 5A-MBP-His6 Homo sapiens 808
psp01848 TDP-43 12A-MBP-His6 Homo sapiens 808
psp02500 TDP-43-MBP-His6 Homo sapiens 787
psp03453 TDP-43 2A-MBP-His6 Homo sapiens 808
psp04034 TDP-43 12D-MBP-His6 Homo sapiens 808
psp04928 TDP-43-MBP-His6 Homo sapiens 808
psp05145 TDP-43 5D-MBP-His6 Homo sapiens 808
psp00025 TDP-43 M337V Homo sapiens 414
psp00089 TDP-43 K181E Homo sapiens 414
psp00128 TDP-43 (W385G) Homo sapiens 414
psp00183 TDP-43 (M337P) Homo sapiens 414
psp00367 TDP-43 (G294A) Homo sapiens 414
psp00461 TDP-43 (W412G) Homo sapiens 414
psp00490 TDP-43 (W334G) Homo sapiens 414
psp00582 TDP-43 (A326P) Homo sapiens 414
psp00726 TDP-43 HPmut5 Homo sapiens 414
psp00818 TDP-43 S48E Homo sapiens 414
psp00848 TDP-43 5D Homo sapiens 414
psp00966 TDP-43(F147L, F149L) Homo sapiens 414
psp01108 TDP-43 12D Homo sapiens 414
psp01141 TDP-43 (G335A) Homo sapiens 414
psp01340 TDP-43 A315E Homo sapiens 414
psp01786 TDP-43(F147L,F149L,F229L,F231L) Homo sapiens 414
psp02029 TDP-43 (W334G/W412G) Homo sapiens 414
psp02214 TDP-43 RRMm Homo sapiens 414
psp02256 TDP-43 (K84R) Homo sapiens 414
psp02265 TDP-43 (Q331K) Homo sapiens 414
psp02295 TDP-43 12A Homo sapiens 414
psp02305 TDP-43 6M&RRMm Homo sapiens 414
psp02306 TDP-43 2KQ Homo sapiens 414
psp02345 TDP-43 5FL Homo sapiens 414
psp02666 TDP-43 S292E Homo sapiens 414
psp02875 TDP-43 P112H Homo sapiens 414
psp03056 TDP-43(Y4R,E17R) Homo sapiens 414
psp03287 TDP-43 R293F Homo sapiens 414
psp03292 TDP-43-NESmut Homo sapiens 414
psp03414 TDP-43 G376D Homo sapiens 414
psp04118 TDP-43 S292:S409:S410E Homo sapiens 414
psp04191 TDP-43 5A Homo sapiens 414
psp04192 TDP-43 G294V Homo sapiens 414
psp04217 TDP-43 K263E Homo sapiens 414
psp04221 TDP-43 (K136Q) Homo sapiens 414
psp04312 TDP-43 2A Homo sapiens 414
psp04440 TDP-43 2D Homo sapiens 414
psp04446 TDP-43 G376V Homo sapiens 414
psp04491 TDP-43 S409:S410E Homo sapiens 414
psp04785 TDP-43 6M Homo sapiens 414
psp05066 TDP-43 (W385G/W412G) Homo sapiens 414
psp00072 TDP43-LCD (267-414) Homo sapiens 148
psp00336 TDP-43 ΔN(102-414) Homo sapiens 313
psp00476 TDP-43 1-274 ΔRRM2 Homo sapiens 203
psp00644 TDP-43Δ40-53 Homo sapiens 400
psp00813 TDP-43 1-274 Homo sapiens 274
psp00845 TDP-43 332-342 Homo sapiens 11
psp00853 TDP-43Δ76-100 Homo sapiens 389
psp00940 TDP-43 RRM1-2(102-269) Homo sapiens 168
psp01106 TDP-43 (Δ274-319) Homo sapiens 369
psp01416 TDP-43 (Δ316-346) Homo sapiens 383
psp01672 TDP-43 (Δ320-366) Homo sapiens 367
psp01741 TDP-43 332-348 Homo sapiens 17
psp01830 TDP-43 312-327 Homo sapiens 16
psp02094 TDP-43 NTD Homo sapiens 79
psp02316 TDP-43 (1-260) Homo sapiens 260
psp02358 Trx-TDP-43 (311−360) Homo sapiens 50
psp02560 TDP-43 (Δ367-414) Homo sapiens 366
psp02907 TDP-43 LCD (262-414) Homo sapiens 153
psp03010 TDP-43 CTD (263-414) Homo sapiens 152
psp03140 TDP-43ΔCR (321-340) Homo sapiens 394
psp03301 TDP-43 ΔNLS Homo sapiens 397
psp03309 TDP-43 193-414 Homo sapiens 222
psp03330 TDP-43 329-348 Homo sapiens 20
psp03337 TDP43 1-273 Homo sapiens 273
psp03457 TDP-43 312-318 Homo sapiens 7
psp03597 TDP-43 1-274 ΔRRM1 Homo sapiens 198
psp03779 TDP43 100-273 Homo sapiens 174
psp03861 TDP-43 (Δ320-414) Homo sapiens 319
psp04050 TDP-43 NTD (1-102) Homo sapiens 102
psp04161 TDP-43C(258-414) Homo sapiens 157
psp04410 TDP-43 ΔC(1-269) Homo sapiens 269
psp04484 TDP-43 312-348 Homo sapiens 37
psp04729 TDP-43(1-101) Homo sapiens 101
psp04742 TDP-43 274-414 Homo sapiens 141
psp04865 TDP-43 LCD Homo sapiens 149
psp04909 TDP-43 316-323 Homo sapiens 8
psp00006 TDP-43 LC A328G Homo sapiens 153
psp00029 TDP-43 CTD L340A Homo sapiens 148
psp00076 TDP-43 LC P280G Homo sapiens 153
psp00125 TDP-43 CTD S317A Homo sapiens 148
psp00162 TDP-43 LCD F6-P3 Homo sapiens 153
psp00173 TDP-43 LC L340G Homo sapiens 153
psp00179 TDP-43 LCD F6-P4 Homo sapiens 153
psp00187 TDP-43 LCD F6-P1 Homo sapiens 153
psp00332 TDP-43 LC M322G Homo sapiens 153
psp00366 TDP-43 LCD F6-P2 Homo sapiens 153
psp00378 TDP-43 LC A326G Homo sapiens 153
psp00434 TDP-43 CTD G335N Homo sapiens 148
psp00439 TDP-43 LC P320A Homo sapiens 153
psp00503 TDP-43 LC M337G Homo sapiens 153
psp00634 TDP-43 LC Q331G Homo sapiens 153
psp00753 TDP43 CTD VLIM-F Homo sapiens 152
psp00782 TDP-43 LC P320G Homo sapiens 153
psp00867 TDP-43 LC S332G Homo sapiens 153
psp00998 TDP-43 LC G335S Homo sapiens 153
psp01029 TDP-43 LCD F6-P6 Homo sapiens 153
psp01038 TDP-43 267-414 A321G Homo sapiens 148
psp01087 TDP-43 CTD G335S Homo sapiens 148
psp01143 TDP43 CTD K-R Homo sapiens 152
psp01271 TDP43 CTD FYW-S Homo sapiens 152
psp01306 TDP-43 LCD F6-P7 Homo sapiens 153
psp01404 S333D TDP-43 LCD Homo sapiens 148
psp01424 TDP43 CTD KRED-S Homo sapiens 152
psp01473 TDP-43 CTD M336A Homo sapiens 148
psp01479 TDP-43 LC A325G Homo sapiens 153
psp01507 TDP-43 LC A315G Homo sapiens 153
psp01526 TDP-43 267-414 A321V Homo sapiens 148
psp01627 TDP43 CTD M-V Homo sapiens 152
psp01747 TDP-43 LCD F6-P5 Homo sapiens 153
psp01763 TDP-43 LC W334G Homo sapiens 153
psp01839 TDP-43 CTD Q331A Homo sapiens 148
psp01850 TDP-43 CTD S332A Homo sapiens 148
psp01894 TDP-43 CTD Q327A Homo sapiens 148
psp01924 TDP-43 LC P320S Homo sapiens 153
psp01935 TDP-43 LC M339G Homo sapiens 153
psp02019 TDP-43 193-414 A315T Homo sapiens 222
psp02041 TDP-43 267-414 (W334F/W385F/W412F) Homo sapiens 148
psp02066 TDP-43 LC M337V Homo sapiens 153
psp02081 TDP-43 CTD G335A Homo sapiens 148
psp02229 TDP-43 LC P363G Homo sapiens 153
psp02260 TDP-43 LC N319G Homo sapiens 153
psp02350 TDP-43 LC A329G Homo sapiens 153
psp02408 TDP-43 CTD I318A Homo sapiens 148
psp02425 TDP-43 CTD M323A Homo sapiens 148
psp02487 TDP-43 LC F316G Homo sapiens 153
psp02618 TDP43 CTD F-Y Homo sapiens 152
psp02665 TDP-43 LC Q327G Homo sapiens 153
psp02754 TDP-43 LC A324G Homo sapiens 153
psp02893 TDP-43 267-414 M337V Homo sapiens 148
psp02909 TDP-43 LC G338S Homo sapiens 153
psp02959 TDP-43 LC S317G Homo sapiens 153
psp03081 TDP-43 CTD Q343A Homo sapiens 148
psp03138 TDP-43 CTD L330A Homo sapiens 148
psp03338 TDP-43 CTD S333A Homo sapiens 148
psp03343 TDP43 CTD F-S Homo sapiens 152
psp03385 TDP-43 CTD N319A Homo sapiens 148
psp03406 TDP-43 CTD M337A Homo sapiens 148
psp03446 TDP-43 CTD M339A Homo sapiens 148
psp03470 TDP-43 CTD M322A Homo sapiens 148
psp03524 TDP-43 CTD F316A Homo sapiens 148
psp03527 TDP43 CTD R-K Homo sapiens 152
psp03611 TDP-43 CTD W334A Homo sapiens 148
psp03685 TDP-43 CTD S342A Homo sapiens 148
psp04006 TDP-43 LC I318G Homo sapiens 153
psp04072 TDP-43 LCD (2-PM) Homo sapiens 149
psp04092 TDP-43 LCD F6-P8 Homo sapiens 153
psp04146 TDP-43 LC L330G Homo sapiens 153
psp04159 TDP-43 LC P349G Homo sapiens 153
psp04198 TDP-43 CTD G335D Homo sapiens 148
psp04201 TDP-43 CTD F313A Homo sapiens 148
psp04342 S332D TDP-43 LCD Homo sapiens 148
psp04343 TDP43 CTD M-S Homo sapiens 152
psp04344 TDP-43 LC M323G Homo sapiens 153
psp04642 TDP-43-K145/192R Homo sapiens 274
psp04657 TDP-43 LC S333G Homo sapiens 153
psp04722 TDP-43 CTD G338A Homo sapiens 148
psp04739 TDP-43 1-274 D169G Homo sapiens 203
psp04770 TDP-43 LC A321G Homo sapiens 153
psp04776 TDP-43 LC M336G Homo sapiens 153
psp05171 TDP-43 LCD (4-PM) Homo sapiens 149

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence