ASK3 NT

ID psp04244
Organism Homo sapiens
Length 622

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33649309 - Negative

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01762 ASK3 1-1313 - ✓
psp04244 ASK3 NT 1-622 -
psp00355 ASK3 KD 623-911 -
psp02819 ASK3 CT 905-1313 -
psp04496 ASK3 ΔN 623-1313 -
psp05170 ASK3 ΔC 1-911 -
psp00916 ASK3 PBM2 - R203A, R204A
psp01022 ASK3 T808A - T808A
psp01997 ASK3 PBM10 - K895A, R896A
psp02363 ASK3 PBM8 - R493A, R494A, K496A, K497A
psp02948 ASK3 K681M - K681M
psp03442 ASK3 PBM4 - R332A, R333A
psp03752 ASK3 PBM9 - K797A, R798A
psp03820 ASK3 PBM5 - R391A, K392A
psp03837 ASK3 PBM6 - R424A, K425A
psp04154 ASK3 PBM7 - R436A, K437A
psp04264 ASK3 PBM1 - R58A, R59A
psp04527 ASK3 PBM3 - R252A, K253A, R255A

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

The chart can zoom in and zoom out by mouse wheel.

IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence