ASK3 PBM4
PS Record in Articles
| Reference (Pubmed ID) | In vitro results | In vivo results |
|---|---|---|
| 33649309 | Positive | Positive |
Protein Sequence
Sequence Variants
| ID | Name | Remain region | Mutation sites | Ref seq |
|---|---|---|---|---|
| psp01762 | ASK3 | 1-1313 | - | ✓ |
| psp03442 | ASK3 PBM4 | - | R332A, R333A | |
| psp00355 | ASK3 KD | 623-911 | - | |
| psp02819 | ASK3 CT | 905-1313 | - | |
| psp04244 | ASK3 NT | 1-622 | - | |
| psp04496 | ASK3 ΔN | 623-1313 | - | |
| psp05170 | ASK3 ΔC | 1-911 | - | |
| psp00916 | ASK3 PBM2 | - | R203A, R204A | |
| psp01022 | ASK3 T808A | - | T808A | |
| psp01997 | ASK3 PBM10 | - | K895A, R896A | |
| psp02363 | ASK3 PBM8 | - | R493A, R494A, K496A, K497A | |
| psp02948 | ASK3 K681M | - | K681M | |
| psp03752 | ASK3 PBM9 | - | K797A, R798A | |
| psp03820 | ASK3 PBM5 | - | R391A, K392A | |
| psp03837 | ASK3 PBM6 | - | R424A, K425A | |
| psp04154 | ASK3 PBM7 | - | R436A, K437A | |
| psp04264 | ASK3 PBM1 | - | R58A, R59A | |
| psp04527 | ASK3 PBM3 | - | R252A, K253A, R255A |
Orthologs and Paralogs
Biophysical Features
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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.
Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.
NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.
Polarity was computated by ProtScale, please refer to: ProtScale.
SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.
Protein Structure
Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.
For pLDDT, please refer to: pLDDT: Understanding local confidence