FUS_(PLD_6D)
ID
psp03599
Organism
Homo sapiens
Length
211
Protein Sequence
Sequence Variants
| ID | Name | Remain region | Mutation sites | Ref seq |
|---|---|---|---|---|
| psp01156 | FUS | 1-526 | - | ✓ |
| psp03599 | FUS_(PLD_6D) | 1-211 | G15D, S26D, G34D, S39D, S42D, G51D | |
| psp00401 | FUS RGG3-PY | 450-526 | - | |
| psp00681 | FUS IDR | 1-237 | - | |
| psp00835 | FUS RGG (371-526) | 371-526 | - | |
| psp01014 | FUS 1-215 | 1-215 | - | |
| psp01023 | FUS (215-267) | 215-267 | - | |
| psp01144 | FUS 1-211 | 1-211 | - | |
| psp01277 | FUS 1-267 | 1-267 | - | |
| psp01727 | 0.5N FUS (1-106) | 1-106 | - | |
| psp01746 | FUS PrD (1-173) | 1-173 | - | |
| psp02189 | FUS (1-214) | 1-214 | - | |
| psp02352 | FUS exon3-5 | 14-174 | - | |
| psp02356 | FUS-RGG3 | 472-504, 526-526 | - | |
| psp02491 | FUSN | 1-212 | - | |
| psp02593 | FUS LC-RGG1 (1-284) | 1-284 | - | |
| psp02709 | FUS (2-214) | 2-214 | - | |
| psp02814 | 0.75 FUS (1-156) | 1-156 | - | |
| psp03169 | 0.5C FUS (107-214) | 107-214 | - | |
| psp03419 | FUS RBD | 212-526 | - | |
| psp03971 | FUS CTD (267-526) | 267-526 | - | |
| psp04280 | FUS(1-180) | 1-180 | - | |
| psp04426 | FUS RGG (211-526∆422-453) | 211-421, 454-526 | - | |
| psp04486 | FUS-IDR | 1-210 | - | |
| psp04926 | FUS LC | 1-163 | - | |
| psp05176 | FUS Δ14 | 1-465 | - | |
| psp00658 | FUS G225V | - | G225V | |
| psp00798 | FUS R244K | - | R244K | |
| psp00836 | FUS ncY→F | - | Y113F, Y122F, Y130F, Y136F, Y143F, Y149F, Y155F, Y161F | |
| psp01246 | FUS R521C | - | R521C | |
| psp01939 | FUS (P525L) | - | P525L | |
| psp02259 | FUS 6R→A | - | R216A, R259A, R407A, R472A, R473A, R476A | |
| psp02292 | FUS G399V | - | G399V | |
| psp02402 | FUS4 FL | - | F305L, F341L, F359L, F368L | |
| psp02925 | FUS R244C | - | R244C | |
| psp03078 | FUS G156E | - | G156E | |
| psp03322 | FUS ncY→A | - | Y113A, Y122A, Y130A, Y136A, Y143A, Y149A, Y161A | |
| psp03341 | FUS G187S | - | G187S | |
| psp03714 | FUS 6R→K | - | R216K, R259K, R407K, R472K, R473K, R476K | |
| psp04470 | FUS R521G | - | R521G | |
| psp05107 | FUS-all-KGG | - | R213K, R218K, R244K, R248K, R251K, R259K, R377K, R383K, R388K, R394K, R407K, R473K, R476K, R481K, R487K, R491K, R495K, R498K, R503K | |
| psp00651 | FUS 6E | 1-163 | T7E, T11E, T19E, S26E, S30E, S42E | |
| psp00831 | FUS LC Q→N | 1-163 | Q8N, Q9N, Q12N, Q20N, Q23N, Q27N, Q28N, Q31N, Q35N, Q36N, Q43N, Q52N, Q60N, Q62N, Q69N, Q73N, Q85N, Q88N, Q93N, Q94N, Q102N, Q103N, Q118N, Q124N, Q126N, Q132N, Q133N, Q139N, Q140N, Q141N, Q145N, Q146N, Q147N, Q153N, Q157N, Q158N, Q160N | |
| psp00965 | FUS LC-RGG1 (Q→A) | 1-284 | Q8A, Q9A, Q12A, Q20A, Q23A, Q27A, Q28A, Q31A, Q35A, Q36A, Q43A, Q52A, Q60A, Q62A, Q69A, Q73A, Q85A, Q88A, Q93A, Q94A, Q102A, Q103A, Q118A, Q124A, Q126A, Q132A, Q133A, Q139A, Q140A, Q141A, Q145A, Q146A, Q147A, Q153A, Q157A, Q158A, Q160A | |
| psp01011 | FUS LC-RGG1 T→S | 1-284 | T7S, T11S, T19S, T45S, T47S, T64S, T68S, T71S, T78S, T109S | |
| psp01291 | FUS LC 4QQ→SS | 1-163 | Q27S, Q28S, Q93S, Q94S, Q132S, Q133S, Q157S, Q158S | |
| psp01307 | FUS LC-RGG1 S→G | 1-284 | S3G, S13G, S26G, S29G, S30G, S37G, S39G, S42G, S44G, S48G, S53G, S54G, S56G, S57G, S61G, S70G, S77G, S83G, S84G, S86G, S87G, S89G, S90G, S95G, S96G, S107G, S108G, S110G, S112G, S115G, S116G, S117G, S119G, S120G, S121G, S127G, S129G, S131G, S135G, S142G, S148G, S163G | |
| psp01366 | FUS-LC (G156E) | 1-163 | G156E | |
| psp01450 | FUS LC T→S | 1-163 | T7S, T11S, T19S, T45S, T47S, T64S, T68S, T71S, T78S, T109S | |
| psp01551 | FUS LC (Q→A) | 1-163 | Q8A, Q9A, Q12A, Q20A, Q23A, Q27A, Q28A, Q31A, Q35A, Q36A, Q43A, Q52A, Q60A, Q62A, Q69A, Q73A, Q85A, Q88A, Q93A, Q94A, Q102A, Q103A, Q118A, Q124A, Q126A, Q132A, Q133A, Q139A, Q140A, Q141A, Q145A, Q146A, Q147A, Q153A, Q157A, Q158A, Q160A | |
| psp01635 | FUS_PLD_(Y→S) | 1-211 | Y6S, Y14S, Y17S, Y25S, Y33S, Y38S, Y41S, Y50S, Y55S, Y58S, Y66S, Y75S, Y81S, Y91S, Y97S, Y100S, Y113S, Y122S, Y130S, Y136S, Y143S, Y149S, Y155S, Y161S, Y177S, Y194S, Y208S | |
| psp01659 | FUS LC (12S→A) | 1-163 | S30A, S44A, S48A, S53A, S70A, S84A, S95A, S108A, S117A, S119A, S127A | |
| psp01668 | FUS LC 12S→G | 1-163 | S30G, S44G, S48G, S53G, S70G, S84G, S89G, S95G, S108G, S117G, S119G, S127G | |
| psp01776 | FUS LC-RGG1 Q→S | 1-284 | Q8S, Q9S, Q12S, Q20S, Q23S, Q27S, Q28S, Q31S, Q35S, Q36S, Q43S, Q52S, Q60S, Q62S, Q69S, Q73S, Q85S, Q88S, Q93S, Q94S, Q102S, Q103S, Q118S, Q124S, Q126S, Q132S, Q133S, Q139S, Q140S, Q141S, Q145S, Q146S, Q147S, Q153S, Q157S, Q158S, Q160S | |
| psp02003 | FUS LC T→V | 1-163 | T7V, T11V, T19V, T45V, T47V, T64V, T68V, T71V, T78V, T109V | |
| psp02699 | FUS LC 12S→N | 1-163 | S30N, S44N, S48N, S53N, S70N, S84N, S89N, S95N, S108N, S117N, S119N, S127N | |
| psp03065 | FUS LC 4S→A#1 | 1-163 | S30A, S44A, S48A, S53A | |
| psp03532 | FUS LC 4QQ→AA | 1-163 | Q27A, Q28A, Q93A, Q94A, Q132A, Q133A, Q157A, Q158A | |
| psp03547 | FUS 12E | 1-163 | T7E, T11E, T19E, S26E, S30E, S42E, S61E, T68E, S84E, S87E, S117E, S131E | |
| psp03702 | FUS LC 4QQ→GG | 1-163 | Q27G, Q28G, Q93G, Q94G, Q132G, Q133G, Q157G, Q158G | |
| psp03727 | FUS LC 4QQ→NN | 1-163 | Q27N, Q28N, Q93N, Q94N, Q132N, Q133N, Q157N, Q158N | |
| psp03774 | FUS LC-RGG1 Q→G | 1-284 | Q8G, Q9G, Q12G, Q20G, Q23G, Q27G, Q28G, Q31G, Q35G, Q36G, Q43G, Q52G, Q60G, Q62G, Q69G, Q73G, Q85G, Q88G, Q93G, Q94G, Q102G, Q103G, Q118G, Q124G, Q126G, Q132G, Q133G, Q139G, Q140G, Q141G, Q145G, Q146G, Q147G, Q153G, Q157G, Q158G, Q160G | |
| psp03925 | FUS LC-RGG1 (Q→N) | 1-284 | Q8N, Q9N, Q12N, Q20N, Q23N, Q27N, Q28N, Q31N, Q35N, Q36N, Q43N, Q52N, Q60N, Q62N, Q69N, Q73N, Q85N, Q88N, Q93N, Q94N, Q102N, Q103N, Q118N, Q124N, Q126N, Q132N, Q133N, Q139N, Q140N, Q141N, Q145N, Q146N, Q147N, Q153N, Q157N, Q158N, Q160N | |
| psp04336 | FUS LC (S→G) | 1-162, 515-515 | S3G, S13G, S26G, S29G, S30G, S37G, S39G, S42G, S44G, S48G, S53G, S54G, S56G, S57G, S61G, S70G, S77G, S83G, S84G, S86G, S87G, S89G, S90G, S95G, S96G, S107G, S108G, S110G, S112G, S115G, S116G, S117G, S119G, S120G, S121G, S127G, S129G, S131G, S135G, S142G, S148G | |
| psp04370 | FUS_PLD_(G/S/T→D) | 1-211 | T7D, G15D, S26D, G34D, S39D, S42D, G51D, S56D, G59D, G67D, G76D, G82D, G92D, G99D, G101D, G114D, G123D, S131D, G137D, G144D, G156D, G178D, G195D, G209D | |
| psp04417 | FUS LC 4S→A (70,84,89,95) | 1-163 | S70A, S84A, S89A, S95A | |
| psp04539 | FUS LC 12S→Q | 1-163 | S30Q, S44Q, S48Q, S53Q, S70Q, S84Q, S89Q, S95Q, S108Q, S117Q, S119Q, S127Q | |
| psp04900 | FUS LC-RGG1 T→V | 1-284 | T7V, T11V, T19V, T45V, T47V, T64V, T68V, T71V, T78V, T109V | |
| psp04930 | FUS 468-526 SGG | 468-526 | R473S, R476S, R481S, R485S, R487S, R491S, R495S, R498S, R503S, R514S | |
| psp04967 | FUS LC 12S→A | 1-163 | S30A, S44A, S48A, S53A, S70A, S84A, S89A, S95A, S108A, S117A, S119A, S127A | |
| psp05093 | FUS LC 4S→A#3 | 1-163 | S108A, S117A, S119A, S127A | |
| psp05193 | FUSm-ΔRRM (Δ285-371) | 1-284, 372-526 | G156E | |
| psp00008 | FUS-LC | - | - | |
| psp00016 | FUS-IDR-FREE1 | - | - | |
| psp00026 | MBP-PdhR-FUSN | - | - | |
| psp00035 | FUS 2XPLD | - | - | |
| psp00036 | FUS+5R | - | - | |
| psp00066 | FUS-CHOP ΔDBD (type II) | - | - | |
| psp00178 | FUS(1-266)-CHOP-eGFP | - | - | |
| psp00182 | FUS-TPPP CORE | - | - | |
| psp00297 | FUS-phyB Y276H ΔNTE | - | - | |
| psp00599 | FUS(1-175)-CHOP-eGFP | - | - | |
| psp00900 | FUS-CHOP type I Δ50-75 | - | - | |
| psp01099 | FUS_(PLD_Y→S) | - | - | |
| psp01119 | FUS_27R_(del-NLS) | - | - | |
| psp01266 | FUS-CHOP type I Δ75 | - | - | |
| psp01338 | FUS_(RBD_R→G) | - | - | |
| psp01351 | FUS+7R | - | - | |
| psp01503 | MBP-FUS-CHOP | - | - | |
| psp01874 | FUS-CHOP type I Δ75-125 | - | - | |
| psp01886 | FUS-CHOP type I Δ125 | - | - | |
| psp01945 | FUSm-IDR-FREE1 | - | - | |
| psp02267 | FUS-PLP | - | - | |
| psp02360 | FUS_PLD_→_EWSR1_RBD | - | - | |
| psp02460 | FUS CTD-mCherry | - | - | |
| psp02742 | FUS LC Charge+32.seg | - | - | |
| psp02805 | MBP-FUS | - | - | |
| psp02845 | FUS-TIS | - | - | |
| psp02956 | FUS+9R | - | - | |
| psp02964 | FUS_PLD_→_hnRNPA1a_RBD | - | - | |
| psp03317 | FUS_(RBD_R→K) | - | - | |
| psp03550 | FUS IDR-ARID1A | - | - | |
| psp03647 | FUS_27R | - | - | |
| psp03692 | FUS-Gal4 | - | - | |
| psp03718 | FUS_(PLD_Y→F_RBD_R→K) | - | - | |
| psp03778 | FUS LC +20Tyr | - | - | |
| psp03858 | FUS | - | - | |
| psp03936 | FUS-CHOP type I Δ50 | - | - | |
| psp04015 | 1.5 FUS | - | - | |
| psp04074 | FUS LC Charge+42.seg | - | - | |
| psp04102 | FUS+21R | - | - | |
| psp04126 | MBP-FUSN | - | - | |
| psp04129 | FUS LC +30Tyr | - | - | |
| psp04189 | FUS IDR-JunB Δ296-322 | - | - | |
| psp04194 | FUS-CHOP | - | - | |
| psp04220 | FUS_(PLD_Y→F) | - | - | |
| psp04378 | FUS_(PLD_Q→G) | - | - | |
| psp04384 | FUS_(PLD_G→A) | - | - | |
| psp04730 | FUS-CHOP type I Δ25 | - | - | |
| psp04731 | FUS LC+R2 | - | - | |
| psp04756 | FUS-CHOP ΔDBD (type I) | - | - | |
| psp04762 | FUS+16R | - | - | |
| psp04783 | FUS-CHOP type I Δ50-125 | - | - | |
| psp04905 | FUS 2XPLD halfYtoS | - | - | |
| psp04931 | 2.0 FUS | - | - | |
| psp05025 | FUS+16R ncY→A | - | - | |
| psp05037 | (FUS LC)2 | - | - | |
| psp05100 | FUS-DDIT3 | - | - | |
| psp05172 | FUS_(PLD_S→A) | - | - |
Orthologs and Paralogs
| ID | Name | Organism | Length |
|---|---|---|---|
| psp03712 | TaSR45a-FUS | Triticum aestivum | 485 |
| psp05003 | PdhR-FUSN-His6 | Synthetic | 503 |
Biophysical Features
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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.
Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.
NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.
Polarity was computated by ProtScale, please refer to: ProtScale.
SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.
Protein Structure
Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.
For pLDDT, please refer to: pLDDT: Understanding local confidence