SHP2-PTP

ID psp03497
Organism Homo sapiens
Length 253

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33002410 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02027 SHP2 1-593 - ✓
psp03497 SHP2-PTP 272-524 -
psp03933 SHP2ΔC 1-524 -
psp01353 SHP2 R498L - R498L
psp01977 SHP2 E76K - E76K
psp02264 SHP2 Y279C - Y279C
psp03091 SHP2 E76A - E76A
psp03433 SHP2 D61G - D61G
psp03574 SHP2 Y279C/R362E/K364E - Y279C, R362E, K364E
psp03732 SHP2 R498L/R362E/K364E - R362E, K364E, R498L
psp03765 SHP2 E76K/R362E/K364E - E76K, R362E, K364E
psp03879 SHP2 G464A - G464A
psp03921 SHP2 Q506P - Q526P
psp04412 SHP2 E76A/R362E/K364E - E76A, R362E, K364E
psp02928 SHP2 PTP R362E/K364E 272-524 R362E, K364E

Orthologs and Paralogs

ID Name Organism Length
psp01714 SHP1 Homo sapiens 595
psp00969 SHP1-del C(1-532) Homo sapiens 532
psp02428 SHP1-PTP(218-528) Homo sapiens 311
psp00796 SHP1-PTP K360E Homo sapiens 311
psp01802 SHP1-PTP K358E/R360E Homo sapiens 311
psp02291 SHP1-PTP R358E Homo sapiens 311

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence