SHP1-PTP K360E

ID psp00796
Organism Homo sapiens
Length 311

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
35219918 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01714 SHP1 1-595 - ✓
psp00796 SHP1-PTP K360E 218-528 K360E
psp00969 SHP1-del C(1-532) 1-532 -
psp02428 SHP1-PTP(218-528) 218-528 -
psp01802 SHP1-PTP K358E/R360E 218-528 R358E, K360E
psp02291 SHP1-PTP R358E 218-528 R358E

Orthologs and Paralogs

ID Name Organism Length
psp02027 SHP2 Homo sapiens 593
psp01353 SHP2 R498L Homo sapiens 593
psp01977 SHP2 E76K Homo sapiens 593
psp02264 SHP2 Y279C Homo sapiens 593
psp03091 SHP2 E76A Homo sapiens 593
psp03433 SHP2 D61G Homo sapiens 593
psp03574 SHP2 Y279C/R362E/K364E Homo sapiens 593
psp03732 SHP2 R498L/R362E/K364E Homo sapiens 593
psp03765 SHP2 E76K/R362E/K364E Homo sapiens 593
psp03879 SHP2 G464A Homo sapiens 593
psp03921 SHP2 Q506P Homo sapiens 593
psp04412 SHP2 E76A/R362E/K364E Homo sapiens 593
psp03497 SHP2-PTP Homo sapiens 253
psp03933 SHP2ΔC Homo sapiens 524
psp02928 SHP2 PTP R362E/K364E Homo sapiens 253

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence