BRD4 exon14-15

ID psp03040
Organism Mus musculus
Length 321

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
34605568 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00017 BRD4 1-1400 -
psp03040 BRD4 exon14-15 739-1059 -

Orthologs and Paralogs

ID Name Organism Length
psp01349 BRD4L Homo sapiens 1362
psp00212 BRD3 Homo sapiens 726
psp01030 BRD3 F334S Homo sapiens 726
psp00645 BRD4 NPS-ET Homo sapiens 222
psp00781 BRD4 (674-1351) Homo sapiens 678
psp01520 BRD4 BD2 Homo sapiens 114
psp02039 BRD4 BD1-BD2 (44-477) Homo sapiens 434
psp02303 BRD4 BD2-CPS (347-720) Homo sapiens 347
psp02330 BRD4 BD2-ET Homo sapiens 347
psp02357 BRD4 BD1-linker Homo sapiens 306
psp02391 BRD4-IDR(ΔP1&P2) Homo sapiens 500
psp02656 BRD4 linker-BD2 Homo sapiens 295
psp03327 BRD4S (1-719) Homo sapiens 719
psp03452 BRD4 BID-ET Homo sapiens 160
psp03622 BRD4 BD2-BID Homo sapiens 233
psp04162 BRD4 601-683 Homo sapiens 83
psp04184 BRD4 BD1 Homo sapiens 125
psp04525 BRD4 NPS-BID Homo sapiens 118
psp04557 BRD4 BD2-BID#2 Homo sapiens 219
psp05087 BRD4-IDR (721-1351) Homo sapiens 631

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence