BRD4 BD2

ID psp01520
Organism Homo sapiens
Length 114

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
32203489 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01349 BRD4L 1-1362 - ✓
psp01520 BRD4 BD2 347-460 -
psp00645 BRD4 NPS-ET 462-683 -
psp00781 BRD4 (674-1351) 674-1351 -
psp02039 BRD4 BD1-BD2 (44-477) 44-477 -
psp02303 BRD4 BD2-CPS (347-720) 374-720 -
psp02330 BRD4 BD2-ET 347-693 -
psp02357 BRD4 BD1-linker 44-349 -
psp02391 BRD4-IDR(ΔP1&P2) 721-750, 801-950, 1032-1351 -
psp02656 BRD4 linker-BD2 163-457 -
psp03327 BRD4S (1-719) 1-719 -
psp03452 BRD4 BID-ET 524-683 -
psp03622 BRD4 BD2-BID 347-579 -
psp04162 BRD4 601-683 601-683 -
psp04184 BRD4 BD1 44-168 -
psp04525 BRD4 NPS-BID 462-579 -
psp04557 BRD4 BD2-BID#2 347-565 -
psp05087 BRD4-IDR (721-1351) 721-1351 -

Orthologs and Paralogs

ID Name Organism Length
psp00212 BRD3 Homo sapiens 726
psp01030 BRD3 F334S Homo sapiens 726
psp03040 BRD4 exon14-15 Mus musculus 321

Biophysical Features

The chart can zoom in and zoom out by mouse wheel.

IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence