USP10 C424A

ID psp02798
Organism Homo sapiens
Length 798

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37611590 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01677 USP10 1-798 - ✓
psp02798 USP10 C424A - C424A
psp02035 USP10 ΔDUB ΔPBR 1-142, 164-413 -
psp03729 USP10 ΔDUB (1-414) 1-414 -

Orthologs and Paralogs

ID Name Organism Length
psp01549 USP51 Homo sapiens 711
psp01898 USP6 Homo sapiens 1406
psp04325 USP39 Homo sapiens 565
psp01723 USP2 Homo sapiens 605
psp02272 USP49 Homo sapiens 212
psp03640 USP36 Homo sapiens 1123
psp00520 USP39-(184-565) Homo sapiens 382
psp00595 USP39-ΔC Homo sapiens 555
psp01429 USP39-ΔN Homo sapiens 462
psp01618 USP39-N(1-103) Homo sapiens 103
psp04748 USP39-ΔUBP Homo sapiens 501
psp00795 USP42 Homo sapiens 1316
psp00379 USP42-C120A Homo sapiens 1316
psp01983 USP42-R (Δ742-937, Δ1176-1246) Homo sapiens 1049
psp02008 USP42-(742-1316) Homo sapiens 575
psp02169 USP42-ΔP (Δ742-937) Homo sapiens 1120
psp02171 USP42-ΔK (Δ1176-1246) Homo sapiens 1245
psp02771 USP42-ΔR (Δ948-1118) Homo sapiens 1145
psp03498 USP42-K (Δ742-937, Δ948-1118) Homo sapiens 949
psp04033 USP42-P (Δ1176-1246, Δ948-1118) Homo sapiens 1174

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence