USP42-C120A

ID psp00379
Organism Homo sapiens
Length 1316

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33731873 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00795 USP42 1-1316 - ✓
psp00379 USP42-C120A - C120A
psp01983 USP42-R (Δ742-937, Δ1176-1246) 1-741, 938-1175, 1247-1316 -
psp02008 USP42-(742-1316) 742-1316 -
psp02169 USP42-ΔP (Δ742-937) 1-741, 938-1316 -
psp02171 USP42-ΔK (Δ1176-1246) 1-1175, 1247-1316 -
psp02771 USP42-ΔR (Δ948-1118) 1-947, 1119-1316 -
psp03498 USP42-K (Δ742-937, Δ948-1118) 1-741, 938-947, 1119-1316 -
psp04033 USP42-P (Δ1176-1246, Δ948-1118) 1-947, 1019-1175, 1247-1316 -

Orthologs and Paralogs

ID Name Organism Length
psp01677 USP10 Homo sapiens 798
psp01549 USP51 Homo sapiens 711
psp01898 USP6 Homo sapiens 1406
psp04325 USP39 Homo sapiens 565
psp01723 USP2 Homo sapiens 605
psp02272 USP49 Homo sapiens 212
psp03640 USP36 Homo sapiens 1123
psp02798 USP10 C424A Homo sapiens 798
psp02035 USP10 ΔDUB ΔPBR Homo sapiens 392
psp03729 USP10 ΔDUB (1-414) Homo sapiens 414
psp00520 USP39-(184-565) Homo sapiens 382
psp00595 USP39-ΔC Homo sapiens 555
psp01429 USP39-ΔN Homo sapiens 462
psp01618 USP39-N(1-103) Homo sapiens 103
psp04748 USP39-ΔUBP Homo sapiens 501

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence