α-Synuclein (D2A)

ID psp02052
Organism Homo sapiens
Length 140

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38731658 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01197 α-synuclein 1-140 - ✓
psp02052 α-Synuclein (D2A) - D2A
psp00498 α-synuclein-126 (Δ41-54) 1-40, 55-140 -
psp01709 α-synuclein (1-135) 1-135 -
psp02466 α-Synuclein (30-110) 30-110 -
psp03369 α-synuclein (1-115) 1-115 -
psp03755 α-synuclein (1-122) 1-122 -
psp03882 α-synuclein-112 (Δ103-130) 1-102, 131-140 -
psp04310 α-synuclein-98 (Δ41-54, Δ103-130) 1-40, 55-102, 131-140 -
psp00408 α-synuclein V16I, G68P, V70I - V16I, G68P, V70I
psp00756 α-synuclein A18T - A18T
psp00761 α-synuclein E35K, E46K, E61K - E35K, E46K, E61K
psp00806 α-Synuclein (H50Q) - H50Q
psp01047 α-synuclein G68P, V70I - G68P, V70I
psp01089 α-synuclein V15I, V16I - V15I, V16I
psp01231 α-synuclein V16I - V16I
psp02114 α-Synuclein (A30P) - A30P
psp02621 α-synuclein E83Q - E83Q
psp02908 α-Synuclein (A53T) - A53T
psp04083 α-Synuclein E46K - E46K
psp04255 α-Synuclein (S129E) - S129E
psp05010 α-synuclein A53E - A53E

Orthologs and Paralogs

ID Name Organism Length
psp04695 β-Synuclein Homo sapiens 134
psp01979 γ-Synuclein Homo sapiens 127

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence