γ-Synuclein

Synonyms: Synoretin, PRSN, BCSG1, Persyn, Gamma-synuclein, Breast cancer-specific gene 1 protein, SNCG, SR, PERSYN

ID psp01979
Organism Homo sapiens
Length 127
Source UniProt: O76070

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
32514159 Negative -

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp01197 α-synuclein Homo sapiens 140
psp04695 β-Synuclein Homo sapiens 134
psp00408 α-synuclein V16I, G68P, V70I Homo sapiens 140
psp00756 α-synuclein A18T Homo sapiens 140
psp00761 α-synuclein E35K, E46K, E61K Homo sapiens 140
psp00806 α-Synuclein (H50Q) Homo sapiens 140
psp01047 α-synuclein G68P, V70I Homo sapiens 140
psp01089 α-synuclein V15I, V16I Homo sapiens 140
psp01231 α-synuclein V16I Homo sapiens 140
psp02052 α-Synuclein (D2A) Homo sapiens 140
psp02114 α-Synuclein (A30P) Homo sapiens 140
psp02621 α-synuclein E83Q Homo sapiens 140
psp02908 α-Synuclein (A53T) Homo sapiens 140
psp04083 α-Synuclein E46K Homo sapiens 140
psp04255 α-Synuclein (S129E) Homo sapiens 140
psp05010 α-synuclein A53E Homo sapiens 140
psp00498 α-synuclein-126 (Δ41-54) Homo sapiens 126
psp01709 α-synuclein (1-135) Homo sapiens 135
psp02466 α-Synuclein (30-110) Homo sapiens 81
psp03369 α-synuclein (1-115) Homo sapiens 115
psp03755 α-synuclein (1-122) Homo sapiens 122
psp03882 α-synuclein-112 (Δ103-130) Homo sapiens 112
psp04310 α-synuclein-98 (Δ41-54, Δ103-130) Homo sapiens 98

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence