YTHDF2 YTH

ID psp01940
Organism Homo sapiens
Length 135

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
31292544 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01290 YTHDF2 1-579 - ✓
psp01940 YTHDF2 YTH 410-544 -
psp01318 YTHDF2 284-362 284-362 -
psp01920 YTHDF2 288-388 288-388 -
psp02377 YTHDF2 230-579 230-579 -
psp04467 YTHDF2 230-383 230-383 -
psp00234 YTHDF2aa230-383 (Q to A) 230-383 Q249A, Q250A, Q290A, Q294A, Q298A, Q301A, Q305A, Q309A, Q310A, Q319A, Q324A, Q325A, Q327A, Q335A, Q338A, Q342A, Q343A, Q344A, Q347A, Q373A, Q375A
psp01511 YTHDF2 230-579 (W432A/W486A) 230-579 W432A, W486A

Orthologs and Paralogs

ID Name Organism Length
psp04464 YTHDC1 Homo sapiens 727
psp00828 YTHDF3 Homo sapiens 585
psp02812 YTHDF1 Homo sapiens 559
psp02722 YTHDF1 Mus musculus 559
psp00257 YTHDC1 K82R Homo sapiens 727
psp01006 YTHDC1 K82T Homo sapiens 727
psp01138 YTHDC1 (W377A) Homo sapiens 727
psp01918 YTHDC1 K82Q Homo sapiens 727
psp03275 YTHDC1 (W377A, W428A) Homo sapiens 727
psp04936 YTHDC1 (ΔpolyE) Homo sapiens 674
psp01835 YTHDF3-MUT Homo sapiens 585

Biophysical Features

The chart can zoom in and zoom out by mouse wheel.

IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence