YTHDC1 (W377A)

ID psp01138
Organism Homo sapiens
Length 727

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
34048709 - Negative

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp04464 YTHDC1 1-727 - ✓
psp01138 YTHDC1 (W377A) - W377A
psp04936 YTHDC1 (ΔpolyE) 1-198, 252-727 -
psp00257 YTHDC1 K82R - K82R
psp01006 YTHDC1 K82T - K82T
psp01918 YTHDC1 K82Q - K82Q
psp03275 YTHDC1 (W377A, W428A) - W377A, W428A

Orthologs and Paralogs

ID Name Organism Length
psp01290 YTHDF2 Homo sapiens 579
psp00828 YTHDF3 Homo sapiens 585
psp02812 YTHDF1 Homo sapiens 559
psp02722 YTHDF1 Mus musculus 559
psp01318 YTHDF2 284-362 Homo sapiens 79
psp01920 YTHDF2 288-388 Homo sapiens 101
psp01940 YTHDF2 YTH Homo sapiens 135
psp02377 YTHDF2 230-579 Homo sapiens 350
psp04467 YTHDF2 230-383 Homo sapiens 154
psp00234 YTHDF2aa230-383 (Q to A) Homo sapiens 154
psp01511 YTHDF2 230-579 (W432A/W486A) Homo sapiens 350
psp01835 YTHDF3-MUT Homo sapiens 585

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence