YAP L318E

ID psp01577
Organism Homo sapiens
Length 504

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33606996 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp04598 YAP1 1-504 - ✓
psp01577 YAP L318E - L318E
psp00855 YAP (1-164) 1-164 -
psp01297 YAP (266-504) 266-504 -
psp04042 YAPΔTAD 1-229, 268-297 -
psp00637 YAP 5SA - S61A, S109A, S127A, S164A, S397A
psp01587 YAP L311E - L311E
psp02673 YAP L308/311/325/318E (4LE) - L308E, L311E, L318E, L325E
psp02810 YAP (S127A) - S127A
psp02933 YAP L308E - L308E
psp04099 YAP L325E - L325E
psp02044 YAP S127A ΔCC 1-296, 359-504 S127A
psp02151 YAP S127A ΔsIDR 1-359, 447-504 S127A
psp02634 YAP S127A ΔsTAD 1-449 S127A
psp00793 YAP-MAML2 - -

Orthologs and Paralogs

ID Name Organism Length
psp02816 YAP Homo sapiens 454
psp01301 YAP-WWT+CCT Homo sapiens 439
psp03990 YAP-CCT Homo sapiens 439
psp04518 YAP-WWT Homo sapiens 454
psp01162 YAP1-β S128A Homo sapiens 454
psp04723 YAP1-β S127A Homo sapiens 454
psp02789 YAP Mus musculus 488

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence