YAP1-β S128A

ID psp01162
Organism Homo sapiens
Length 454

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
31792379 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02816 YAP 1-454 - ✓
psp01162 YAP1-β S128A - S128A
psp04723 YAP1-β S127A - S127A
psp01301 YAP-WWT+CCT - -
psp03990 YAP-CCT - -
psp04518 YAP-WWT - -

Orthologs and Paralogs

ID Name Organism Length
psp04598 YAP1 Homo sapiens 504
psp00793 YAP-MAML2 Homo sapiens 1313
psp00637 YAP 5SA Homo sapiens 504
psp01577 YAP L318E Homo sapiens 504
psp01587 YAP L311E Homo sapiens 504
psp02673 YAP L308/311/325/318E (4LE) Homo sapiens 504
psp02810 YAP (S127A) Homo sapiens 504
psp02933 YAP L308E Homo sapiens 504
psp04099 YAP L325E Homo sapiens 504
psp00855 YAP (1-164) Homo sapiens 164
psp01297 YAP (266-504) Homo sapiens 239
psp04042 YAPΔTAD Homo sapiens 259
psp02044 YAP S127A ΔCC Homo sapiens 442
psp02151 YAP S127A ΔsIDR Homo sapiens 417
psp02634 YAP S127A ΔsTAD Homo sapiens 449
psp02789 YAP Mus musculus 488

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence