GATA3 R275A

ID psp01370
Organism Homo sapiens
Length 443

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
40372915 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00483 GATA3 1-443 - ✓
psp01370 GATA3 R275A - R275A
psp00743 GATA3 N-IDR (1-260) 1-260 -
psp01239 GATA3 DBD (261-360) 260-360 -
psp01497 GATA3 ΔDBD 1-259, 362-443 -
psp01926 GATA3 ΔN 260-443 -
psp02380 GATA3 Δ322-327 1-321, 328-443 -
psp02627 GATA3 ΔC 1-360 -
psp03469 GATA3 C-IDR (361-443) 361-443 -
psp05106 GATA3 Δ88-93 1-87, 94-443 -
psp00027 GATA3 R329A - R329A
psp00057 GATA3 R311A - R311A
psp00331 GATA3 R276A - R276A
psp01386 GATA3 K346A - K346A
psp01519 GATA3 ZnF2 2R-K - R305K, R306K
psp01949 GATA3 R261A - R261A
psp01951 GATA3 ZnF2 2R-A - R305A, R306A
psp02321 GATA3 K292A - K292A
psp02484 GATA3 R312A - R312A
psp02602 GATA3 R306A - R306A
psp02718 GATA3 R305A - R305A
psp03615 GATA3 R330A - R330A
psp04054 GATA3 K302A - K302A
psp04237 GATA3 ZnF1 2R-A - R275A, R276A
psp04289 GATA3 K304A - K304A
psp05108 GATA3 ZnF1 2R-K - R275K, R276K

Orthologs and Paralogs

ID Name Organism Length
psp02340 GATA2 Homo sapiens 480

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence