GATA2

Synonyms: GATA2, GATA-binding protein 2, Endothelial transcription factor GATA-2

ID psp02340
Organism Homo sapiens
Length 480
Source UniProt: P23769

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
30449618 Positive -

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp00483 GATA3 Homo sapiens 443
psp00027 GATA3 R329A Homo sapiens 443
psp00057 GATA3 R311A Homo sapiens 443
psp00331 GATA3 R276A Homo sapiens 443
psp01370 GATA3 R275A Homo sapiens 443
psp01386 GATA3 K346A Homo sapiens 443
psp01519 GATA3 ZnF2 2R-K Homo sapiens 443
psp01949 GATA3 R261A Homo sapiens 443
psp01951 GATA3 ZnF2 2R-A Homo sapiens 443
psp02321 GATA3 K292A Homo sapiens 443
psp02484 GATA3 R312A Homo sapiens 443
psp02602 GATA3 R306A Homo sapiens 443
psp02718 GATA3 R305A Homo sapiens 443
psp03615 GATA3 R330A Homo sapiens 443
psp04054 GATA3 K302A Homo sapiens 443
psp04237 GATA3 ZnF1 2R-A Homo sapiens 443
psp04289 GATA3 K304A Homo sapiens 443
psp05108 GATA3 ZnF1 2R-K Homo sapiens 443
psp00743 GATA3 N-IDR (1-260) Homo sapiens 260
psp01239 GATA3 DBD (261-360) Homo sapiens 101
psp01497 GATA3 ΔDBD Homo sapiens 341
psp01926 GATA3 ΔN Homo sapiens 184
psp02380 GATA3 Δ322-327 Homo sapiens 437
psp02627 GATA3 ΔC Homo sapiens 360
psp03469 GATA3 C-IDR (361-443) Homo sapiens 83
psp05106 GATA3 Δ88-93 Homo sapiens 437

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence