HOXD4

Synonyms: HOX4B, Homeobox protein Hox-D4, Homeobox protein Hox-4B, HOXD4, Homeobox protein Hox-5.1, Homeobox protein HHO.C13

ID psp01316
Organism Homo sapiens
Length 255
Source UniProt: P09016

PS Record in Articles

No phase separation records for this protein in the article.

This entry is just use for illustrate the sequence variants relationship.

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01316 HOXD4 1-255 -
psp01986 HOXD4 IDR 1-140 -
psp00194 HOXD4 IDR (AroLITE S) 1-140 Y6S, Y12S, F17S, Y23S, Y28S, Y36S, Y37S, F46S, Y52S, F57S, F62S, Y89S, Y113S, Y134S, W136S
psp00996 HOXD4 IDR (AroLITE A) 1-140 Y6A, Y12A, F17A, Y23A, Y28A, Y36A, Y37A, F46A, Y52A, F57A, F62A, Y89A, Y113A, Y134A, W136A
psp01345 HOXD4 IDR (AroPLUS) 1-140 P69Y, G77Y, G83Y, A98Y, A105Y, Q120Y, L127Y
psp02788 HOXD4 IDR (AroPLUS LITE) 1-140 P69A, G77A, G83A, Q120A, L127A
psp03372 HOXD4 IDR (AroLITE G) 1-140 Y6G, Y12G, F17G, Y23G, Y28G, Y36G, Y37G, F46G, Y52G, F57G, F62G, Y89G, Y113G, Y134G, W136G
psp00642 HOXD4 IDR (AroPLUS patched) - -
psp01094 HOXD4 IDR (AroPERFECT) - -
psp04082 HOXD4 IDR (AroPLUS patched LITE) - -

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence