52K (R/K)

ID psp00754
Organism Human adenovirus 5
Length 415

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
37020020 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp01257 52K 1-415 - ✓
psp00754 52K (R/K) - R6K, R15K, R25K, R54K, R57K, R78K, R86K, R95K, R102K, R113K, R122K, R129K, R141K
psp02098 52K (Δ1-47) 48-415 -
psp01054 52K (Scramble) - R6D, R15D, E17R, R25E, D42R, D48R, R54D, R57E, D61R, E64R, R81E, R86E, D87R, R89E, E90R, R95D, E105R, E108R, K114E, R127E, E128K, R129E, E134R, E137R
psp01899 52K (P/A) - P3A, P10A, P11A, P12A, P27A, P29A, P30A, P31A
psp04603 52K (Q/G) - Q7G, Q13G, Q14G, Q16G, Q18G, Q20G, Q22G

Orthologs and Paralogs

ID Name Organism Length
psp03460 52K Human adenovirus 415
psp03489 52K (S28/75A) Adenovirus 415
psp04032 52K (S28/75D) Adenovirus 415
psp00358 MBP-52K Adenovirus 789
psp03297 MBP-52K (S28/75D) Adenovirus 789
psp03631 MBP-52K (S28/75A) Adenovirus 789

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence