CBX2 ATHL2
Protein Sequence
Sequence Variants
| ID | Name | Remain region | Mutation sites | Ref seq |
|---|---|---|---|---|
| psp04145 | CBX2 | 1-519 | - | ✓ |
| psp00663 | CBX2 ATHL2 | - | R162A, K163A, K164A, R165A, R167A, K168A | |
| psp02482 | CBX2 ΔCD | 66-519 | - | |
| psp04288 | CBX2 ΔCD-ATH | 89-519 | - | |
| psp00491 | CBX2 SRR | - | S106A, S108A, S110A, S112A, S115A, S117A, S119A, S120A | |
| psp00695 | CBX2 ATH | - | P76A, R77A, G78A | |
| psp01534 | CBX2 F12A | - | F12A | |
| psp04432 | CBX2 ATHL1 | - | P135A, R136A, G137A |
Orthologs and Paralogs
| ID | Name | Organism | Length |
|---|---|---|---|
| psp01759 | CBX4 | Homo sapiens | 560 |
| psp01385 | CBX7A | Mus musculus | 251 |
| psp04631 | CBX8 | Mus musculus | 362 |
| psp02218 | CBX2 | Homo sapiens | 532 |
| psp00653 | CBX2AT-P2A | Homo sapiens | 532 |
| psp00844 | CBX2 ATLm | Homo sapiens | 532 |
| psp03189 | CBX2 Atm | Homo sapiens | 532 |
| psp03868 | CBX2 SRR-S2A | Homo sapiens | 532 |
| psp03878 | CBX2 HNCR-N2A | Homo sapiens | 532 |
| psp04441 | CBX2 SRR-S2E | Homo sapiens | 532 |
| psp04852 | CBX2 CA-P2A | Homo sapiens | 532 |
| psp01419 | CBX2 89-532 | Homo sapiens | 444 |
| psp01902 | CBX2 1-281 | Homo sapiens | 281 |
| psp03798 | CBX2 65-532 | Homo sapiens | 468 |
| psp03909 | CBX2 1-192 | Homo sapiens | 192 |
| psp04877 | CBX2 1-498 | Homo sapiens | 498 |
| psp02386 | CBX4-CBox-IIITD mut | Homo sapiens | 560 |
| psp02921 | CBX4-CBox-FKEY mut | Homo sapiens | 560 |
| psp04203 | CBX4-CBox-VTV mut | Homo sapiens | 560 |
| psp04434 | CBX4-CBox-LTVT mut | Homo sapiens | 560 |
| psp00181 | CBX4-dCD (del 1-60) | Homo sapiens | 500 |
| psp00455 | CBX4-dP2 (del 61-269) | Homo sapiens | 351 |
| psp01070 | CBX4-dP3 (del 270-530) | Homo sapiens | 299 |
| psp01233 | CBX4-dCBox (del 531-560) | Homo sapiens | 530 |
| psp02211 | CBX7C | Mus musculus | 166 |
Biophysical Features
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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.
Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.
NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.
Polarity was computated by ProtScale, please refer to: ProtScale.
SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.
Protein Structure
Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.
For pLDDT, please refer to: pLDDT: Understanding local confidence