PRAG1 IDR1-IDR2

ID psp00391
Organism Homo sapiens
Length 829

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
40149915 - Negative

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02796 PRAG1 1-1406 - ✓
psp00391 PRAG1 IDR1-IDR2 116-944 -
psp00038 PRAG1 IDR2 458-944 -
psp01877 PRAG1 IDR1 116-451 -
psp02786 PRAG1 ∆IDR1 1-115, 452-1406 -
psp03002 PRAG1 ∆IDR2 1-457, 945-1406 -
psp03377 PRAG1-∆N (∆948-975) 1-947, 976-1406 -
psp04524 PRAG1 ∆IDR1-IDR2 1-115, 945-1406 -
psp04542 PRAG1-∆J (∆1347-1372) 1-1346, 1373-1406 -
psp00219 PRAG1 Y1282A - Y1282A
psp00416 PRAG1 I1243A - I1243A
psp00440 PRAG1 A1367E - A1367E
psp03033 PRAG1 F1271A - F1271A

Orthologs and Paralogs

ID Name Organism Length
psp01396 PRAG1 Mus musculus 1373

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence