PRAG1

Synonyms: Sugen kinase 223, Sgk223, Nack, Notch activation complex kinase, Tyrosine-protein kinase SgK223, Inactive tyrosine-protein kinase PRAG1, D8Ertd82e, Prag1, PEAK1-related kinase-activating pseudokinase 1

ID psp01396
Organism Mus musculus
Length 1373
Source UniProt: Q571I4

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
40149915 - Positive

Protein Sequence

Sequence Variants

No protein variants available for this protein.

Orthologs and Paralogs

ID Name Organism Length
psp02796 PRAG1 Homo sapiens 1406
psp00219 PRAG1 Y1282A Homo sapiens 1406
psp00416 PRAG1 I1243A Homo sapiens 1406
psp00440 PRAG1 A1367E Homo sapiens 1406
psp03033 PRAG1 F1271A Homo sapiens 1406
psp00038 PRAG1 IDR2 Homo sapiens 487
psp00391 PRAG1 IDR1-IDR2 Homo sapiens 829
psp01877 PRAG1 IDR1 Homo sapiens 336
psp02786 PRAG1 ∆IDR1 Homo sapiens 1070
psp03002 PRAG1 ∆IDR2 Homo sapiens 919
psp03377 PRAG1-∆N (∆948-975) Homo sapiens 1378
psp04524 PRAG1 ∆IDR1-IDR2 Homo sapiens 577
psp04542 PRAG1-∆J (∆1347-1372) Homo sapiens 1380

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence