NBR1

Synonyms: Next to BRCA1 gene 1 protein, Membrane component chromosome 17 surface marker 2 homolog, Nbr1, Neighbor of BRCA1 gene 1 protein, M17s2

ID psp00116
Organism Mus musculus
Length 988
Source UniProt: P97432

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
31916398 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00116 NBR1 1-988 - ✓
psp04242 NBR1 D50R - D50R

Orthologs and Paralogs

ID Name Organism Length
psp03180 AtNBR1 Arabidopsis thaliana 704
psp00250 NBR1 Homo sapiens 966
psp03949 AtNBR1 [WDPI661-664AAAA] Arabidopsis thaliana 704
psp00763 AtNBR1 ΔZZ Arabidopsis thaliana 653
psp01286 AtNBR1 ΔZZ ΔFW Arabidopsis thaliana 502
psp02072 AtNBR1 ΔPB1 Arabidopsis thaliana 618
psp02180 AtNBR1 ΔFW Arabidopsis thaliana 589
psp03571 AtNBR1 ΔUBA ΔZZ ΔFW Arabidopsis thaliana 218

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence