Axin Δ465-496

ID psp00046
Organism Homo sapiens
Length 830

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38279052 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp04148 Axin1 1-862 - ✓
psp00046 Axin Δ465-496 1-464, 497-862 -
psp00184 Axin 209-530 209-530 -
psp00296 Axin Δ531-679 1-530, 680-862 -
psp00328 Axin1 AD5 1-208, 377-405, 465-862 -
psp00643 Axin1 AD2 1-519, 747-862 -
psp00683 Axin1 AD3 1-208, 465-519, 747-862 -
psp00990 Axin1 AD9 1-240, 307-862 -
psp01176 Axin1 AD4 1-375, 407-862 -
psp02275 Axin1 AD6 1-463, 521-862 -
psp02617 Axin1 AD1 1-208, 465-862 -
psp02625 Axin1 AD7 1-208, 377-862 -
psp03022 Axin Δ209-464+Δ497-679 1-208, 465-496, 680-862 -
psp03410 Axin 209-679 209-679 -
psp03567 Axin Δ209-679 1-208, 678-862 -
psp03790 Axin1 AD10 1-279, 306-862 -
psp01711 Axin1 AD7-hnRNPA1 - -
psp01761 Axin1 AD7-TDP43 - -

Orthologs and Paralogs

ID Name Organism Length
psp03995 Axin1 Mus musculus 863
psp04239 Axin Drosophila melanogaster 745

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence