LATS1 (PrLD)

ID psp04673
Organism Homo sapiens
Length 356

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
34267352 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02431 LATS1 1-1130 - ✓
psp04673 LATS1 (PrLD) 168-523 -
psp01828 LATS1 (ΔPrLD) 1-167, 524-1130 -

Orthologs and Paralogs

ID Name Organism Length
psp04893 LATS2 Homo sapiens 1088
psp01391 LATS2 P-to-Q Homo sapiens 1088
psp04495 LATS2 P-to-A Homo sapiens 1088
psp00628 LATS2 Δ464-667 Homo sapiens 884
psp01084 LAST2 ΔLCD1 Homo sapiens 928
psp01594 LAST2 ΔLCD2 Homo sapiens 1026
psp02580 LAST2 Δ668-1033 Homo sapiens 722
psp02787 LAST2 Δ161-402 Homo sapiens 846
psp03141 LATS2 PRM Homo sapiens 242
psp03686 LATS2 Δ1-667 Homo sapiens 421

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence