FOXM1 (d_IDR2)

ID psp04526
Organism Homo sapiens
Length 548

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
39814884 Positive Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp03083 FOXM1 1-763 - ✓
psp04526 FOXM1 (d_IDR2) 1-385, 601-763 -
psp00655 FOXM1 (IDR1) 321-385 -
psp01601 FOXM1 (d_FHD) 1-233, 321-763 -
psp02393 FOXM1 (d_TAD) 1-600 -
psp03919 FOXM1 (d_IDR1) 1-320, 386-763 -
psp04684 FOXM1 (d_NRD) 201-763 -
psp02322 FOXM1 S376E - S376E
psp03039 FOXM1 S376D - S376D
psp04625 FOXM1 S376A - S376A
psp00445 FOXM1 IDR1 V379E 321-385 V379E
psp00510 FOXM1 IDR1 P369A/L370A/L371A/P372A 321-385 P369A, L370A, L371A, P372A
psp01745 FOXM1 IDR1 L378E 321-385 L378E
psp01982 FOXM1 IDR1 L370E/L378E 321-385 L370E, L378E
psp02125 FOXM1 IDR1 L378E/F383E 321-382, 680-682 L378E, L682V
psp02195 FOXM1 IDR1 V385E 321-385 V385E
psp02775 FOXM1 IDR1 L370E 321-385 L370E
psp03263 FOXM1 IDR1 F383A/P384A/V385A 321-382, 402-404 S404A
psp03382 FOXM1 IDR1 L378A/V379A/P380A/I380A 321-385 L378A, V379A, P380A, I381A
psp03620 FOXM1 IDR1 L370E/L378E/F383E 321-382, 680-682 L370E, L378E, L682V
psp03773 FOXM1 IDR1 L370E/F383E 321-382, 680-682 L370E, L682V
psp04251 FOXM1 IDR1 F383E 321-382, 680-682 L682V

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence