CCDC6-RET Δ70-77

ID psp04513
Organism Homo sapiens
Length 495

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38805286 - Negative

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00997 CCDC6-RET 1-503 - ✓
psp04513 CCDC6-RET Δ70-77 - -
psp02675 CCDC6-RET Δ49-51 - -
psp03429 CCDC6-RET ΔPolyG - -
psp03478 CCDC6-RET - -
psp04965 CCDC6-RET Δ21-27 - -

Orthologs and Paralogs

ID Name Organism Length
psp05144 CCDC6 Homo sapiens 474
psp00987 CCDC6-101aa Δ21-27 Homo sapiens 94
psp01184 CCDC6 Δ1-101 Homo sapiens 373
psp01437 CCDC6-293aa Homo sapiens 293
psp02538 CCDC6-101aa Δ49-51 Homo sapiens 98
psp02953 CCDC6 1-101 Homo sapiens 101
psp03437 CCDC6-101aa Δ70-77 Homo sapiens 93
psp03842 CCDC6-150aa Homo sapiens 150
psp04944 CCDC6-ALK Homo sapiens 664
psp01330 CCDC6-ALK K194M Homo sapiens 664

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence