IRE1α LD 350NKLN353-GSGS

ID psp04317
Organism Homo sapiens
Length 420

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
39232130 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02941 IRE1α 1-977 - ✓
psp04317 IRE1α LD 350NKLN353-GSGS 24-443 N350G, K351S, L352G, N353S
psp02205 IRE1α cLD (24-389) 24-389 -
psp04268 IRE1α LD (24-443) 24-443 -
psp00513 IRE1α LD D123P 24-389 D123P
psp00933 IRE1α LD 352LNYL355-GSGS 24-443 L352G, N353S, Y354G, L355S
psp01722 IRE1α LD 359WLLI362-GSGS 24-443 W359G, L360S, L361G, I362S
psp01729 IRE1α LD 346LKSK349-GSGS 24-443 L346G, K347S, S348G, K349S
psp02237 IRE1α LD 320QTDG323-GSGS 24-443 Q320G, T321S, D322G, G323S
psp04013 IRE1α LD 373TKML376-GSGS 24-443 T373G, K374S, M375G, L376S
psp05002 IRE1α LD 312TLPL315-GSGS 24-443 T312G, L313S, P314G, L315S

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence