CPEB4Δ4 ΔNTD

ID psp03904
Organism Homo sapiens
Length 281

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
38943248 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02465 CPEB4 1-729 -
psp03904 CPEB4Δ4 ΔNTD 449-729 -
psp03696 CPEB4 NTD 1-448 -

Orthologs and Paralogs

ID Name Organism Length
psp02071 Cpeb1b Danio rerio 559
psp04114 CPEB3 Homo sapiens 698
psp01378 CPEB2N(1-138) Homo sapiens 138
psp00843 CPEB3 R3 201-450 Homo sapiens 250
psp02752 CPEB3 S8 350-450 Homo sapiens 101
psp03132 CPEB3 S6 250-350 Homo sapiens 101
psp03847 CPEB3 IDR 1-450 Homo sapiens 450
psp04047 CPEB3 R4 301-450 Homo sapiens 150
psp04181 CPEB3 R1 1-200 Homo sapiens 200
psp04377 CPEB3 S7 300-400 Homo sapiens 101
psp04428 CPEB3 S5 201-300 Homo sapiens 100
psp04767 CPEB3 R2 1-300 Homo sapiens 300
psp03523 Cpeb3 1-459 Mus musculus 459
psp04890 CPEB3 294-410 Mus musculus 117

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence