EWSR1_RBD 285-656

ID psp03626
Organism Homo sapiens
Length 372

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
29961577 Negative -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp02511 EWSR1 1-656 - ✓
psp03626 EWSR1_RBD 285-656 285-656 -
psp01035 EWS 445-656 445-656 -
psp01367 EWS-PLP 1-265 -
psp02558 EWS LCD (2-264) 2-264 -
psp02644 EWS LCD 1-280 -
psp03541 EWS 1-285 1-285 -
psp03643 EWSR1_PLD 1-284 1-284 -
psp03797 EWS LCRN (1-264) 1-264 -
psp04276 EWS (47-266) 47-266 -
psp04563 EWS-FLI1 1-265, 272-273, 278-278, 298-299, 312-318, 322-326, 332-354, 358-363, 365-405, 414-416, 424-425, 450-450, 455-457, 460-465, 468-469, 482-494, 505-506, 511-515, 537-538, 558-564, 567-587, 598-627, 635-639, 652-658, 680-712, 732-734, 743-743 -
psp03628 EWS-LCD Y170S/Y172S 1-280 Y170S, Y172S
psp04121 EWS-LCD 7YS 1-280 Y6S, Y21S, Y41S, Y66S, Y98S, Y124S, Y170S

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence