Gpsm2 ΔGL3-4

ID psp03243
Organism Mus musculus
Length 572

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
35687681 - Positive

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp00165 Gpsm2 1-679 - ✓
psp03243 Gpsm2 ΔGL3-4 22-593 -
psp00573 Gpsm2 Δ421-476 1-420, 477-679 -
psp00777 Gpsm2 ΔGL1-2 8-489, 594-679 -
psp01341 Gpsm2 ΔTPR 351-679 -
psp02846 Gpsm2 ΔGL1-4 8-489 -
psp00847 Gpsm2 KA - K36A, K59A, K80A, K103A, K113A, K138A, K155A, K157A, K233A, K238A, K266A, K267A, K276A, K300A, K307A, K316A, K347A, K358A, K402A, K416A, K421A, K432A, K434A, K439A, K443A, K451A, K453A, K454A, K456A, K463A, K481A, K482A, K529A, K532A, K575A, K590A, K591A, K603A, K622A, K641A, K663A, K675A, K679A
psp01221 Gpsm2 R318RfsX8 - -

Orthologs and Paralogs

ID Name Organism Length
psp01238 Gpsm1 Mus musculus 673
psp00524 GP20 Synthetic 40

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence