NFAT5

Synonyms: NF-AT5, TONEBP, KIAA0827, TonE-binding protein, T-cell transcription factor NFAT5, NFAT5, Tonicity-responsive enhancer-binding protein, TonEBP, Nuclear factor of activated T-cells 5

ID psp02649

Organism Homo sapiens

Length 1531

Source UniProt: O94916

PS Record in Articles

Reference (Pubmed ID)	In vitro results	In vivo results
39970224	-	Positive

Protein Sequence

Sequence Variants

ID	Name	Remain region	Mutation sites	Ref seq
psp02649	NFAT5	1-1531	-	✓
psp01628	NFAT5 PLD (999-1454)	999-1454	-
psp05101	NFAT5 CTD (544-1531)	544-1531	-
psp01726	NFAT5 PLD_H>F	-	H1013F, H1066F, H1073F, H1094F, H1101F, H1118F, H1190F, H1236F, H1310F, H1353F, H1423F
psp03248	NFAT5 PLD_H>K	-	H1013K, H1066K, H1073K, H1094K, H1101K, H1118K, H1190K, H1236K, H1310K, H1353K, H1423K

Orthologs and Paralogs

No orthologs or paralogs found for this protein in the database.

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence