TFAM HMGA+linker (43-152)

ID psp02452
Organism Homo sapiens
Length 110

PS Record in Articles

Reference (Pubmed ID) In vitro results In vivo results
33619770 Positive -

Protein Sequence

Sequence Variants

ID Name Remain region Mutation sites Ref seq
psp04265 TFAM 1-246 - ✓
psp02452 TFAM HMGA+linker (43-152) 43-152 -
psp00120 TFAM 43-122 43-122 -
psp00275 TFAM ΔHMGA (123-246) 123-246 -
psp00277 TFAM 122-246 122-246 -
psp00885 TFAM 43-222 43-222 -
psp03247 TFAM ΔC (43-222) 43-222 -
psp04356 TFAM HMGB+C-tail (153-246) 153-246 -
psp04504 TFAM 152-246 152-246 -
psp04700 TFAM 43-246 43-246 -
psp01368 TFAM L6 - K136A, H137A, K139A, R140A, K146A, K147A
psp03662 TFAM no dimer - K95A, Y99F, E106A, E112A, R116A
psp03440 TFAM-6His - -

Orthologs and Paralogs

ID Name Organism Length
psp02441 TFAM1 Solanum lycopersicum 181
psp03736 TFAM1 ΔIDR1 Solanum lycopersicum 137
psp00779 TFAM11 Solanum lycopersicum 218
psp02131 TFAM2 Solanum lycopersicum 204
psp02375 TFAM2 ΔIDR2 Solanum lycopersicum 127
psp03553 TFAM3 Solanum lycopersicum 171
psp00443 TFAM3 ΔIDR1 Solanum lycopersicum 129

Biophysical Features

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IDR (Intrinsically Disordered Region) was predicted by Mobidb-lite 4.0, please refer to: MobiDB-lite 4.0: faster prediction of intrinsic protein disorder and structural compactness.

Pi-Pi interaction was predicted by PScore, please refer to: Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

PLAAC and PrD. like were both predicted by PLAAC, please refer to: PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.

LCR (Low Complexity Region) was predicted by SEG, please refer to: Statistics of local complexity in amino acid sequences and sequence databases.

NCPR (Net Charge Per Residue), FCR (Fraction of Charged Residues) and hydrophobicity were both computated by CIDER, please refer to: CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins.

Polarity was computated by ProtScale, please refer to: ProtScale.

SASA (Solvent-Accessible Surface Area) was computated by BioPython based on the predicted structure, please refer to: Bio.PDB.SASA module.

Protein Structure

Colered by pLDDT:
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

Protein structure was predicted by Chai-1, which also produces predicted local distance difference test (pLDDT) score between 0 and 100.

For pLDDT, please refer to: pLDDT: Understanding local confidence